MAB4423
Anti-SOX-2 Antibody, clone 10H9.1
clone 10H9.1, from mouse
别名:
ANOP3, MCOPS3, MGC2413
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
10H9.1, monoclonal
Species reactivity:
human, mouse
Application:
ICC, WB
Citations:
17
biological source
mouse
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
10H9.1, monoclonal
species reactivity
human, mouse
technique(s)
immunocytochemistry: suitable, western blot: suitable
isotype
IgG2bκ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... SOX2(6657)
mouse ... Sox2(20674)
General description
SOX 2 is also known as SRY related HMG BOX gene 2. All SOX proteins have a single HMG box and bind linear DNA in a sequence-specific manner, resulting in the bending of DNA through large angles. Bending causes the DNA helix to open for some distance, which may affect binding and interactions of other transcription factors. SOX1, SOX2 and SOX3 show the closest homology to SRY. They share maximum homology within the HMG domain and are expressed mainly in the developing nervous system of the mouse. These genes share significant homology outside the HMG box also and are highly conserved throughout their evolution. Sox-2 plays a key role in embryonic stem cell development, and has been shown to help stem cells maintain a pluripotent potential. It has also been shown to be associated with uncommitted dividing stem cell and precursor cells of the developing CNS.
~34 kDa observed
Immunogen
Recombinant protein corresponding to human SOX-2.
Application
Anti-SOX-2 Antibody, clone 10H9.1 detects level of SOX-2 & has been published & validated for use in WB & IC.
Research Category
Stem Cell Research
Stem Cell Research
Research Sub Category
Pluripotent & Early Differentiation
Neural Stem Cells
Pluripotent & Early Differentiation
Neural Stem Cells
Western Blot Analysis: 1.0 µg/mL from a representative lot detected SOX-2 in H9 human stem cell lysate.
Immunocytochemistry Analysis: 10 µg/mL from a representative lot detected SOX-2 in human RenCX cells.
Immunocytochemistry Analysis: 10 µg/mL from a representative lot detected SOX-2 in human RenCX cells.
Physical form
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control
Mouse embryonic stem cells
Mouse embryonic stem cells
Evaluated by Western Blot in mouse embryonic stem cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected SOX-2 in mouse embryonic stem cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected SOX-2 in mouse embryonic stem cell lysate.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Jianghong Man et al.
Cell stem cell, 22(1), 104-118 (2017-12-05)
Tumor hypoxia is associated with poor patient survival and is a characteristic of glioblastoma. Notch signaling is implicated in maintaining glioma stem-like cells (GSCs) within the hypoxic niche, although the molecular mechanisms linking hypoxia to Notch activation have not been
Lanjuan Mi et al.
Frontiers in oncology, 11, 751792-751792 (2021-12-07)
Glioma stem-like cells (GSCs) are a subset of tumor cells that initiate malignant growth and promote the therapeutic resistance of glioblastoma, the most lethal primary brain tumor. Ribosome biogenesis is an essential cellular process to maintain cell growth, but its
Gurkan Mollaoglu et al.
Immunity, 49(4), 764-779 (2018-10-18)
The major types of non-small-cell lung cancer (NSCLC)-squamous cell carcinoma and adenocarcinoma-have distinct immune microenvironments. We developed a genetic model of squamous NSCLC on the basis of overexpression of the transcription factor Sox2, which specifies lung basal cell fate, and
Aleksandra Beylina et al.
Stem cell research, 53, 102354-102354 (2021-06-06)
Mutations in leucine-rich repeat kinase 2 (LRRK2) are associated with inherited forms of Parkinson's disease (PD), causing disease by a gain of kinase function. Here, we describe a series of isogenic iPSC lines with any of five pathogenic mutations (N1437H
Ana Joana Duarte et al.
Stem cell research, 45, 101794-101794 (2020-05-11)
Fabry Disease (FD) is a multisystemic X-linked disorder that belongs to the group of lysosomal storage disorders (LSDs). Causal mutations on alpha-galactosidase A (α-Gal A) commonly lead to abnormal protein and consequently to FD. Since it is an X-linked disease
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