MAB5354
Anti-Amyloid Precursor Protein (APP) Antibody
CHEMICON®, mouse monoclonal, 4.1
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关于此项目
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Clone:
4.1, monoclonal
Species reactivity:
human
Application:
ELISA, IHC, WB
Citations:
2
产品名称
Anti-Amyloid β Precursor Protein Antibody, KPI domain, clone 4.1, clone 4.1, Chemicon®, from mouse
biological source
mouse
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
4.1, monoclonal
species reactivity
human
manufacturer/tradename
Chemicon®
technique(s)
ELISA: suitable, immunohistochemistry: suitable, western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... APP(351)
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Immunogen
Epitope: KPI domain
Purified recombinant KPI domain of Amyloid-beta precursor protein.
Application
Anti-Amyloid β Precursor Protein Antibody, KPI domain, clone 4.1 detects level of Amyloid β Precursor Protein & has been published & validated for use in ELISA, WB, IH.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neurodegenerative Diseases
Neurodegenerative Diseases
Western blot: 2-5 μg/mL using ECL on human brain or platelets. Recognizes a protein of 100-120 kDa.
Immunohistochemistry: 2-5 μg/mL on frozen tissue sections.
ELISA: 1 μg/mL in a direct assay and 10 μg/mL in an indirect assay.
Optimal working dilutions must be determined by the end user.
Immunohistochemistry: 2-5 μg/mL on frozen tissue sections.
ELISA: 1 μg/mL in a direct assay and 10 μg/mL in an indirect assay.
Optimal working dilutions must be determined by the end user.
Biochem/physiol Actions
Amyloid-beta Precursor Protein, KPI (Kunitz protease inhibitor) domain. The antibody reacts with both native and recombinant protein. The antibody has been shown to partially inhibit protease inhibitory properties.
Physical form
Format: Purified
Purified immunoglobulin. Liquid in 20 mM Sodium phosphate buffer with 150 mM NaCl.
Preparation Note
Maintain at 2-8°C in undiluted aliquots for up to 6 months of date of receipt.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Jochen Winterer et al.
Cell reports, 19(6), 1110-1116 (2017-05-13)
The distinctive firing pattern of grid cells in the medial entorhinal cortex (MEC) supports its role in the representation of space. It is widely believed that the hexagonal firing field of grid cells emerges from neural dynamics that depend on
Activation of extrasynaptic, but not synaptic, NMDA receptors modifies amyloid precursor protein expression pattern and increases amyloid-? production.
Bordji, K; Becerril-Ortega, J; Nicole, O; Buisson, A
The Journal of Neuroscience null
相关内容
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