MAB5354
Anti-Amyloid Precursor Protein (APP) Antibody
CHEMICON®, mouse monoclonal, 4.1
别名:
Anti-AAA, Anti-ABETA, Anti-ABPP, Anti-AD1, Anti-APPI, Anti-CTFgamma, Anti-CVAP, Anti-PN-II, Anti-PN2, Anti-alpha-sAPP, Anti-preA4
产品名称
Anti-Amyloid β Precursor Protein Antibody, KPI domain, clone 4.1, clone 4.1, Chemicon®, from mouse
生物来源
mouse
质量水平
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
4.1, monoclonal
种属反应性
human
制造商/商品名称
Chemicon®
技术
ELISA: suitable
immunohistochemistry: suitable
western blot: suitable
同位素/亚型
IgG1
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... APP(351)
免疫原
Epitope: KPI domain
Purified recombinant KPI domain of Amyloid-beta precursor protein.
应用
Anti-Amyloid β Precursor Protein Antibody, KPI domain, clone 4.1 detects level of Amyloid β Precursor Protein & has been published & validated for use in ELISA, WB, IH.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neurodegenerative Diseases
Neurodegenerative Diseases
Western blot: 2-5 μg/mL using ECL on human brain or platelets. Recognizes a protein of 100-120 kDa.
Immunohistochemistry: 2-5 μg/mL on frozen tissue sections.
ELISA: 1 μg/mL in a direct assay and 10 μg/mL in an indirect assay.
Optimal working dilutions must be determined by the end user.
Immunohistochemistry: 2-5 μg/mL on frozen tissue sections.
ELISA: 1 μg/mL in a direct assay and 10 μg/mL in an indirect assay.
Optimal working dilutions must be determined by the end user.
生化/生理作用
Amyloid-beta Precursor Protein, KPI (Kunitz protease inhibitor) domain. The antibody reacts with both native and recombinant protein. The antibody has been shown to partially inhibit protease inhibitory properties.
外形
Format: Purified
Purified immunoglobulin. Liquid in 20 mM Sodium phosphate buffer with 150 mM NaCl.
制备说明
Maintain at 2-8°C in undiluted aliquots for up to 6 months of date of receipt.
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
法律信息
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Jochen Winterer et al.
Cell reports, 19(6), 1110-1116 (2017-05-13)
The distinctive firing pattern of grid cells in the medial entorhinal cortex (MEC) supports its role in the representation of space. It is widely believed that the hexagonal firing field of grid cells emerges from neural dynamics that depend on
Activation of extrasynaptic, but not synaptic, NMDA receptors modifies amyloid precursor protein expression pattern and increases amyloid-? production.
Bordji, K; Becerril-Ortega, J; Nicole, O; Buisson, A
The Journal of Neuroscience null
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