biological source
mouse
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
monoclonal
species reactivity
mouse, rat, human
manufacturer/tradename
Chemicon®
technique(s)
immunocytochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... TOR1B(27348)
General description
37kDa
TorsinA can regulate the cellular trafficking of the dopamine transporter, as well as other polytopic membrane-bound proteins, including G protein-coupled receptors, transporters, and ion channels. TorsinA is found in the dopamine neurons that are lost in PD, and is a component of Lewy bodies. in addition, a genetic defect in TorsinA underlies Torsion dystonia, a disease characterized by painful muscle contractions that result in uncontrollable distortions.
Immunogen
Maltose binding protein fusion protein from human torsinA.
Application
Research Category
Neuroscience
Neuroscience
Research Sub Category
Developmental Neuroscience
Neurodegenerative Diseases
Developmental Neuroscience
Neurodegenerative Diseases
This Anti-TorsinA Antibody is validated for use in IP, WB, IC for the detection of TorsinA.
Biochem/physiol Actions
TorsinA
Physical form
Ascites
Liquid. Contaings no preservative
Preparation Note
Maintain at -20°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles.
Analysis Note
Control
Positive Control: Human brain lysate, NGF treated PC12 cells.
Positive Control: Human brain lysate, NGF treated PC12 cells.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Diminishing evidence for torsinA-positive neuronal inclusions in DYT1 dystonia.
Drew Pratt et al.
Acta neuropathologica communications, 4(1), 85-85 (2016-08-18)
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