MABC209
Anti-MUC13 Antibody, clone 2E11.1
clone 2E11.1, from mouse
别名:
Mucin-13, MUC-13, Down-regulated in colon cancer 1
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
2E11.1, monoclonal
Application:
IHC, WB
Citations:
4
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
2E11.1, monoclonal
species reactivity
human, rat
technique(s)
immunohistochemistry: suitable (paraffin), western blot: suitable
isotype
IgG2aκ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... MUC13(56667)
General description
Mucin-13 (MUC-13) is also called Down-regulated in colon cancer 1 (DRCC1). MUC-13 is an epithelial and hemopoietic transmembrane mucin that is likely involved in cell signaling. MUC-13 is highly expressed in epithelial tissues (especially in gastrointestinal and respiratory tracts) as well as kidney, small intestine, appendix and stomach.
~33 and ~60 kDa observed. Swiss-Prot describes a molecular weight of ~55 kDa Due post-translational modification, this protein is cleaved resulting in beta subunit (~33 kDa) and an alpha subunit (Williams, S. J., et al. (2001). J Biol Chem. 276(21):18327-18336. Maher, D. M., et al. (2011). Mol Cancer Res. 9(5):531-537.). Uncharacterized band(s) may be observed in some cell lysates.
Immunogen
Epitope: This antibody recognizes the cytoplasmic domain within the Beta subunit of MUC-13.
GST-tagged recombinant protein corresponding to the cytoplasmic domain of human MUC-13.
Application
Research Sub Category
Apoptosis - Additional
Apoptosis - Additional
Western Blotting Analysis: 0.5 µg/mL from a representative lot detected MUC-13 in 10 µg of human kidney tissue lysate.
Immunohistochemistry Analysis: a 1:500 dilution from a representative lot detected MUC-13 in human ilium tissues.
Immunohistochemistry Analysis: a 1:500 dilution from a representative lot detected MUC-13 in human ilium tissues.
Detect Mucin using this mouse monoclonal antibody, Anti-MUC13 Antibody, clone 2E11.1 validated for use in western blotting & IHC (Paraffin).
Research Category
Apoptosis & Cancer
Apoptosis & Cancer
Physical form
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Evaluated by Western Blotting in human small intestine tissue lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected MUC-13 in 10 µg of human small intestine tissue lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected MUC-13 in 10 µg of human small intestine tissue lysate.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Mucin-microbiome signatures shape the tumor microenvironment in gastric cancer.
Oosterlinck, et al.
Microbiome, 11, 86-86 (2023)
IL-22-Activated MUC13 Impacts on Colonic Barrier Function through JAK1/STAT3, SNAI1/ZEB1 and ROCK2/MAPK Signaling.
Breugelmans, et al.
Cells, 12 (2023)
Tom Breugelmans et al.
Inflammatory bowel diseases, 29(4), 589-601 (2022-10-15)
Intestinal mucosal healing is nowadays preferred as the therapeutic endpoint in inflammatory bowel disease (IBD), but objective measurements at the molecular level are lacking. Because dysregulated mucin expression is suggested to be involved in mucosal barrier dysfunction in IBD, we
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