MABC48
Anti-Anterior gradient protein 2 homolog Antibody, clone 7A10
clone 7A10, from mouse
别名:
anterior gradient homolog 2 (Xenopus laevis), anterior gradient 2 homolog, protein disulfide isomerase family A, member 17, Secreted cement gland protein XAG-2 homolog, anterior gradient protein 2 homolog, secreted cement gland homolog, anterior gradient
产品名称
Anti-Anterior gradient protein 2 homolog Antibody, clone 7A10, clone 7A10, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
7A10, monoclonal
species reactivity
human
technique(s)
immunocytochemistry: suitable
western blot: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... AGR2(10551)
Analysis Note
Control
MCF-7 cell lysate
MCF-7 cell lysate
Evaluated by Western Blot in MCF-7 cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected Anterior gradient protein 2 homolog in 10 µg of MCF-7 cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected Anterior gradient protein 2 homolog in 10 µg of MCF-7 cell lysate.
Application
Anti-Anterior gradient protein 2 homolog Antibody, clone 7A10 is an antibody against Anterior gradient protein 2 homolog for use in WB & IC.
Immunocytochemistry Analysis: A previous lot was used by an independent laboratory in IC on primary carcinomas (Barraclough, D., et al. (2009). Am J Pathol. 175:1848–1857).
Research Category
Apoptosis & Cancer
Apoptosis & Cancer
Research Sub Category
Tumor Markers
Tumor Markers
Biochem/physiol Actions
Specific for Anterior gradient protein 2 homolog and does not detect Anterior gradient protein 3 homolog.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Anterior gradient protein 2 homolog (AGR2) (also known as secreted cement gland protein XAG-2 homolog) is thought to be a metastasis-inducing protein in breast cancer models and may be used as a means of detecting the outcome of hormonally treated patients with breast cancer. AGR2 may also play an important role in intestinal mucus production. Recent researched has also linked AGR2 to metastasis. Lower levels of AGR expression in prostate cancer may be highly predictive of the reoccurrence of disease even after a prostatectomy.
~18 kDa observed
Immunogen
Linear peptide corresponding to a sequence unique to human Anterior gradient protein 2 homolog and not to human Anterior gradient protein 3 homolog.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Physical form
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
未找到合适的产品？
试试我们的产品选型工具.
存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
The metastasis-inducing protein AGR2 is O-glycosylated upon secretion from mammary epithelial cells.
Christopher Clarke et al.
Molecular and cellular biochemistry, 408(1-2), 245-252 (2015-07-15)
AGR2 is overexpressed in multiple cancers, particularly those arising from breast and prostate tissues, and higher levels of AGR2 are associated with earlier patient death. Although AGR2 is normally resident within the endoplasmic reticulum, the protein has been found in
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持