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Merck
CN

MABC552

Anti-Kallikrein-1/KLK1 Antibody, clone 11C7.1

clone 11C7.1, from mouse

别名:

Kallikrein-1, Kidney/pancreas/salivary gland kallikrein, Tissue kallikrein, Kallikrein-1/KLK1

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
11C7.1, monoclonal
Application:
immunohistochemistry
western blot
Species reactivity:
human
Citations:
Technique(s):
immunohistochemistry: suitable (paraffin)
western blot: suitable
Uniprot accession no.:
P06870

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产品名称

Anti-Kallikrein-1/KLK1 Antibody, clone 11C7.1, clone 11C7.1, from mouse

biological source

mouse

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

11C7.1, monoclonal

species reactivity

human

technique(s)

immunohistochemistry: suitable (paraffin)
western blot: suitable

isotype

IgG2bκ

NCBI accession no.

NP_002248

UniProt accession no.

P06870

shipped in

dry ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... KLK1(3816)

Analysis Note

Evaluated by Western Blotting in human salivary gland tissue lysate.

Western Blotting Analysis: 0.2 µg/mL of this antibody detected Kallikrein-1/KLK1 in 10 µg of human salivary gland tissue lysate.

Application

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Kallikrein-1/KLK1 in human pancreas and human colon tissue.
This Anti-Kallikrein-1/KLK1 Antibody, clone 11C7.1 is validated for use in Western Blotting, Immunohistochemistry (Paraffin) for the detection of Kallikrein-1/KLK1.

General description

Kallikrein-1 (EC:3.4.21.35; UniProt P06870; also known as Glandular kallikrein 1, hK1, Kallikrein serine protease 1, Kidney/pancreas/salivary gland kallikrein, Renal/pancreas/salivary kallikrein 1, Tissue kallikrein) is encoded by the KLK1 (also known as KLKR) gene (Gene ID 3816) in human. Kallikrein-1 is a member of the kallikrein subfamily of serine proteases, members of which are involved in diverse physiological functions and many are used clinically as biomarkers for cancer. Kallikrein-1 is initially produced as a preproprotein with a signal (aa 1-18) and a propeptide (aa 19-24), cleavage of which releases the mature protein (aa 25-262). Kallikrein-1 is the major kallikrein expressed in the kidney, where it generates kinins (e.g. lysyl-bradykinin and bradykinin) and plays role in kidney function and blood pressure regulation through vasodilatory and natriuretic effects. Decreased kidney Kallikrein-1 level is reported in experimental settings of hypertension, diabetic nephropathy, high salt- and aminoglycoside-induced kidney injury.
~30 kDa observed. 28.9 kDa/isoform 1 and 23.8 kDa/isoform 2 calculated.

Immunogen

GST-tagged recombinant protein corresponding to the C-terminal half of human Kallikrein-1/KLK1.

Other Notes

Concentration: Please refer to lot specific datasheet.

Physical form

Format: Purified

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存储类别

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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White Paper: Further considerations of antibody validation and usage.
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A major focus of breast cancer research is to understand the mechanisms responsible for disease progression and drug resistance. Toward that end, it has been found that approximately two thirds of all human breast carcinomas overexpress the Estrogen Receptor α (ERα) protein and it remains the primary pharmacological target for endocrine therapy1,2. The normal cellular function of ERα is as a transcription factor that mediates a wide variety of physiological processes, many of which are dependent upon phosphorylation of the receptor at specific amino acid residues3,4. Indeed, ERα is known to be phosphorylated at a multitude of different sites, yet how these all correlate to disease remains unclear5. Here, we interrogated multiple sites of ERα for phosphorylation status by screening an extensive panel of different breast cancer patient samples and other non-breast cancer tissue microarray (TMA) slide samples to determine their relevance to disease.

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