MABC730
Anti-SCARB1 Antibody, clone 5B8.2
clone 5B8.2, 1 mg/mL, from mouse
别名:
Scavenger receptor class B member 1, SRB1, CD36 and LIMPII analogous 1, CLA-1, CD36 antigen-like 1, Collagen type I receptor, thrombospondin receptor-like 1, SR-BI, CD36
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
5B8.2, monoclonal
Application:
immunohistochemistry
western blot
western blot
Species reactivity:
human
Citations:
1
Technique(s):
immunohistochemistry: suitable
western blot: suitable
western blot: suitable
Uniprot accession no.:
产品名称
Anti-SCARB1 Antibody, clone 5B8.2, clone 5B8.2, 1 mg/mL, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
5B8.2, monoclonal
species reactivity
human
concentration
1 mg/mL
technique(s)
immunohistochemistry: suitable
western blot: suitable
isotype
IgMκ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SCARB1(949)
Analysis Note
Evaluated by Western Blotting in human adrenal tissue lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected SCARB1 in 10 µg of human adrenal tissue lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected SCARB1 in 10 µg of human adrenal tissue lysate.
Application
Detect SCARB1 using this Anti-SCARB1 Antibody, clone 5B8.2 validated for use in western blotting & IHC.
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected SCARB1 in human adrenal gland tissue.
Research Category
Apoptosis & Cancer
Apoptosis & Cancer
Research Sub Category
Apoptosis - Additional
Apoptosis - Additional
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Scavenger receptor class B member 1 (SCARB1), or CD36L1, is the membrane bound cell surface receptor for high density lipoprotein (HDL) as well as a number of related compounds such as phospholipids, cholesterol ester, and phosphatidylserine and apoptotic cells (via their expression of phosphatidylserine on their extracellular surfaces). SCARB1 is also the receptor for Hepatitis C virus glycoprotein E2 and it facilitates the attachment and entry of HCV. SCARB1 plays a critical role in cholesterol homeostasis and mediates cholesterol transfer to and from the HDL protein carriers, a process known as reverse cholesterol transport. It is highly expressed in tissues that require free cholesterol such as the liver and steroidogenic tissues (adrenals, testis, ovary). SCARB1 expression has also been associated with particular cancers including chronic myeloid leukemia (CML), breast cancer, bladder carcinoma, and prostate cancer.
~61 kDa observed. Uncharacterized band(s) may appear in some lysates.
Immunogen
Epitope: Extracellular domain
KLH-conjugated linear peptide corresponding to the extracellular domain of human SCARB1.
Physical form
Format: Purified
Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Shai White-Gilbertson et al.
Scientific reports, 12(1), 8971-8971 (2022-05-28)
Polyploid Giant Cancer Cells (PGCC) are increasingly being recognized as drivers of cancer recurrence. Therapy stress promotes the formation of these cells, which upon stress cessation often successfully generate more aggressive progeny that repopulate the tumor. Therefore, identification of potential
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