MABE61
抗-macro-H2A1.2抗体，克隆14G7
clone 14G7, from mouse
别名:
H2A histone family, member Y, Histone macroH2A1, Medulloblastoma antigen MU-MB-50.205, histone macroH2A1.1, histone macroH2A1.2, Core histone macro-H2A.1
产品名称
抗-macro-H2A1.2抗体，克隆14G7, clone 14G7, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
14G7, monoclonal
species reactivity
human
technique(s)
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... H2AFJ(55766)
Analysis Note
对照
MCF-7细胞裂解物
MCF-7细胞裂解物
通过蛋白质印迹法在MCF-7细胞裂解物中进行评估。
蛋白质印迹分析：0.25 µg/mL该抗体在10 µg MCF-7细胞裂解物中检测到macro-H2A1.2。
蛋白质印迹分析：0.25 µg/mL该抗体在10 µg MCF-7细胞裂解物中检测到macro-H2A1.2。
Application
免疫组织化学分析： 一个代表性批次已被独立实验室用于IH。（Sporn，J.C.，et al.（2009）.Oncogene.1–6.）
免疫细胞化学分析： 一个代表性批次已被独立实验室用于IC。（Sporn，J.C.，et al.（2009）.Oncogene.1–6.）
免疫细胞化学分析： 一个代表性批次已被独立实验室用于IC。（Sporn，J.C.，et al.（2009）.Oncogene.1–6.）
抗macro-H2A1.2抗体，克隆14G7是用于检测macro-H2A1.2（也称为H2A组蛋白家族成员Y或组蛋白macroH2A1）的小鼠单克隆抗体，&已在WBI、CC&IHC中进行了验证。
研究子类别
组蛋白
组蛋白
研究类别
表观遗传学&核功能
表观遗传学&核功能
Disclaimer
除非我们的目录或产品随附的其他公司文件中另有说明，否则我们的产品预期仅用于研究用途，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或对人类或动物的任何类型的消费或应用。
General description
组蛋白MacroH2A（mH2A），也称为H2AFY，是与浓缩的、无活性的异染色质相关的脊椎动物特异性组蛋白变体。 该组蛋白变体由与大的非组蛋白区域融合的组蛋白H2A样结构域组成。已显示mH2A在转录起始水平上抑制RNA聚合酶II驱动的转录。mH2A的非组蛋白区域直接参与转录的抑制、组蛋白乙酰化和阻断SWI/SNF和ACF核小体重塑。该变体组蛋白富含雌性非活性X染色体的染色质和高度甲基化的CpG基因座。
观测分子量〜39 kDa
Immunogen
带有GST标记的重组蛋白，对应于人macro-H2A1.2。
Other Notes
浓度：关于批次特定浓度请参见检验报告。
Physical form
形式：纯化
纯化的小鼠单克隆IgG2bλ，溶于含0.1 M Tris-甘氨酸（pH 7.4）、150 mM NaCl和0.05％叠氮化钠的缓冲液中。
蛋白G
Preparation Note
自接收之日起，在2-8°C下可稳定保存1年。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Recent integrative epigenome analyses highlight the importance of functionally distinct chromatin states for accurate cell function. How these states are established and maintained is a matter of intense investigation. Here, we present evidence for DNA damage as an unexpected means
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The histone demethylase KDM5A erases histone H3 lysine 4 methylation, which is involved in transcription and DNA damage responses (DDRs). While DDR functions of KDM5A have been identified, how KDM5A recognizes DNA lesion sites within chromatin is unknown. Here, we
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