产品名称
抗组蛋白抗体（Pan，克隆F152.C25.WJJ）, clone F152C25W, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
F152C25W, monoclonal
species reactivity
human, bovine
technique(s)
ELISA: suitable
western blot: suitable
isotype
IgG2aκ
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... H2AC21(317772)
Analysis Note
对照
Jurkat细胞裂解液
Jurkat细胞裂解液
通过蛋白质印迹对Jurkat细胞裂解液进行了评估。
蛋白质印迹分析：0.5 µg/mL该抗体在10 µg Jurkat细胞裂解液中检测到组蛋白H1 。
蛋白质印迹分析：0.5 µg/mL该抗体在10 µg Jurkat细胞裂解液中检测到组蛋白H1 。
Application
ELISA分析： 一个代表性批次已被独立实验室用于ELISA。 (Mizoguchi, E., et al. (1997).Gastroenterology.113:1828-1835）。
抗组蛋白抗体（克隆F152.C25.WJJ）是一种用于检测组蛋白（也称组蛋白H1.4、组蛋白H1b）的小鼠单克隆抗体 &已在WB、ELISA中得到验证。
研究子类别
组蛋白
组蛋白
研究类别
表观遗传学&核功能
表观遗传学&核功能
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
观测值~14-33 kDa
该抗体可检测组蛋白H1和核小体核心蛋白组蛋白H2a、H2b、H3、 H4。核小体将DNA包裹并压缩到染色质中，从而限制了DNA进入需要DNA作为模板的细胞机制的可及性。它们在转录调节、DNA修复、DNA复制和染色体稳定性中起着核心作用。DNA的可及性是通过对组蛋白进行复杂的翻译后修饰（也称为组蛋白编码）和核小体重塑来调节的。
组蛋白H1 是一种细胞核蛋白，是核小体链缩合进入高阶结构（higher order structure）所必需的。
组蛋白H1 是一种细胞核蛋白，是核小体链缩合进入高阶结构（higher order structure）所必需的。
Other Notes
替代：MAB052
浓度：请参考批次特异性浓缩物的检验报告。
Physical form
形式：纯化
纯化的小鼠单克隆IgG2aκ，溶于含有0.1 M Tris-甘氨酸（pH 7.4，150 mM NaCl）和0.05％叠氮化钠的缓冲液中。
蛋白G
Preparation Note
自收到之日起，在2-8°C条件下可稳定保存1年。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Zeynep Eren-Ghiani et al.
Cell reports, 13(11), 2327-2335 (2015-12-18)
The formation of motile spermatozoa involves the highly conserved formation of protamine-rich, tightly packed chromatin. However, genetic loss of protamine function in Drosophila and mice does not lead to significant decompaction of sperm chromatin. This indicates that other proteins act
Vanessa de Carvalho Oliveira et al.
Frontiers in immunology, 14, 1042686-1042686 (2023-02-11)
Neutrophil extracellular traps (NETs) serve to immobilize and kill pathogens, but also can contribute to the progression of several inflammatory and auto-immune diseases, as well as cancer. Whence the importance of elucidating the mechanisms underlying NET formation. In this regard
Drosophila protamine-like Mst35Ba and Mst35Bb are required for proper sperm nuclear morphology but are dispensable for male fertility.
Tirmarche, S; Kimura, S; Sapey-Triomphe, L; Sullivan, W; Landmann, F; Loppin, B
G3 (Bethesda, Md.) null
Louise D McCullough et al.
The Journal of clinical investigation, 131(17) (2021-09-29)
Inter-α inhibitor proteins (IAIPs) are a family of endogenous plasma and extracellular matrix molecules. IAIPs suppress proinflammatory cytokines, limit excess complement activation, and bind extracellular histones to form IAIP-histone complexes, leading to neutralization of histone-associated cytotoxicity in models of sepsis.
Rupinder Kaur et al.
PLoS biology, 22(3), e3002573-e3002573 (2024-03-28)
The rising interest and success in deploying inherited microorganisms and cytoplasmic incompatibility (CI) for vector control strategies necessitate an explanation of the CI mechanism. Wolbachia-induced CI manifests in the form of embryonic lethality when sperm from Wolbachia-bearing testes fertilize eggs
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