MABF148E
Anti-CD161 (NK1.1) (mouse), FITC, clone PK136 Antibody
clone PK136, from mouse, FITC conjugate
别名:
Killer cell lectin-like receptor subfamily B member 1B allele A, CD161 antigen-like family member B, Lymphocyte antigen 55b (Ly-55b), NKR-P1 34, Natural killer cell surface protein NKR-P1B allele SJL/BALB (NKR-P1B), CD161b, CD161 (NK1.1)
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
FITC conjugate
Clone:
PK136, monoclonal
Application:
FACS
Citations:
-
biological source
mouse
Quality Segment
conjugate
FITC conjugate
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
PK136, monoclonal
species reactivity
mouse
packaging
antibody small pack of 25 μg
technique(s)
flow cytometry: suitable
isotype
IgG2aκ
UniProt accession no.
target post-translational modification
unmodified
Gene Information
mouse ... Klrb1C(17059)
General description
The PK136 antibody is specific for mouse NK1.1, a type II transmembrane lectin-like receptor and member of the killer cell lectin-like receptor (KLR) family. NK1.1 is prominently expressed on natural killer (NK) cells, and is correlated with NK cytotoxic effects toward virus-infected cells and tumor cells. NK1.1 is expressed on subsets of NKT cells in certain mouse strains (C57BL/6, FVB/N, and NZB), yet absent from others (AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129). Putative subsets of NK cells and their expression of NK1.1 antigen are of continuing interest, including NK1.1+/CD117+ (c-Kit) cells reported to be immunosuppressive for CD8+ T cells in a mechanism involving PD-1 and PD-L1 (Ehlers et al. 2012. Endocrinology. 10: 1247).The PK136 antibody may be used for detection of NK1.1 expression on mouse strains including CE, B6, NZB, C58, Ma/My, ST, SJL, and FVB. The antibody is reported to react with an epitope common to NKR-P1B and NKR-P1C alloantigenic forms of NK1.1 (Carlyle et al. 2006. J. Immunol. 176: 7511-7524).
Application
This mouse monoclonal Anti-CD161 (NK1.1) (mouse), FITC, clone PK136, Cat. No. MABF1489 is validated for use in Flow Cytometry, for the detection of CD161 (NK1.1).
Analysis Note
This monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.
Flow Cytometry Analysis: 0.5 μg from a representative lot detected CD161 (NK1.1) in one million C57Bl/6 splenocytes.
Flow Cytometry Analysis: 0.5 μg from a representative lot detected CD161 (NK1.1) in one million C57Bl/6 splenocytes.
Other Notes
Concentration: Please refer to lot specific datasheet.
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