Anti-ARX Antibody, clone 11F6.2

~58 kDa observed. An uncharacterized band may be observed at ~23 kDa in some tissue lysates.

Aristaless-related homeobox protein (ARX) is a transcription factor that plays an important role in the development of the brain, testis, and pancreas. The gene targets and nuclear associations of ARX are less clear, although it has been demonstrated that ARX interacts with the Pax4 promoter. However, over fifty ARX mutations have been identified and the resultant phenotypes have been well studied. ARX mutations are X-linked and lead to various syndromes including X-linked West syndrome; X-linked myoclonic epilepsy; Partington syndrome; and X-linked mental retardation.

GST-tagged recombinant protein corresponding to human ARX.

Detect ARX using this Anti-ARX Antibody, clone 11F6.2 validated for use in Western Blotting, IHC(P).

Immunohistochemistry Analysis: A 1:1,000 dilution from a reprsentative lot detected ARX in human brain tissue.

Research Category
Neuroscience

Research Sub Category
Developmental Neuroscience

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Control
Human pancreas tissue lysate.

Evaluated by Western Blot in human pancreas tissue lysate.

Western Blot Analysis: 2 µg/mL of this antibody detected ARX in 200 µg of human pancreas tissue lysate.

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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