MABN12
Anti-Beta (β)-Amyloid antibody
mouse monoclonal, G2-11
别名:
Alzheimer disease, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, Protease nexin-II, amyloid beta (A4) precursor protein, amyloid beta A4 protein, amyloid beta precursor protein, beta-amyloid peptide, human mRNA for amyloid A4 prec
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关于此项目
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Clone:
G2-11, monoclonal
Species reactivity:
human, mouse
Application:
ELISA, IHC, WB
Citations:
5
产品名称
抗-淀粉样蛋白β42抗体，克隆G2-11, clone G2-11, from mouse
biological source
mouse
Quality Level
antibody form
purified immunoglobulin
clone
G2-11, monoclonal
species reactivity
human, mouse
technique(s)
ELISA: suitable, immunohistochemistry: suitable, western blot: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... APP(351)
General description
4kda
与阿尔茨′海默病(AD)相关的脑和血管斑块主要由淀粉样蛋白β肽(Aβ)组成。Aβ衍生自淀粉样蛋白前体蛋白(APP)的切割，长度在39至43个氨基酸之间变化。Aβ [1-40]、Aβ [1-42]和Aβ [1-43]肽分别来自残基40、42和43后APP的裂解。切割是在最后一个APP处理步骤中通过γ-分泌酶进行的。Aβ[1-40]、[1-42]和[1-43]肽是AD中发生的斑块和缠结的主要成分。Aβ抗体和肽已被开发为阐明AD生物学的工具。
Immunogen
KLH偶联的线性肽，对应于淀粉样蛋白β42的C末端。
表位：C端
Application
研究类别
神经科学
神经科学
ELISA： MABN12抗体的一个代表性批次被用于效价ELISA。 淀粉样β肽检测的特异性如下所示。
抗淀粉样蛋白β42抗体（克隆-G2-11）可检测淀粉样蛋白β42 的水平 & 已有相关文献发表 & 经过验证可用于WB、WB、ELISA、IH.。
研究子类别
神经退行性疾病
神经退行性疾病
Biochem/physiol Actions
该抗体可识别人淀粉样蛋白β42的C末端
Physical form
形式：纯化
纯化的小鼠单克隆IgG1κ溶于含0.1 M Tris-甘氨酸（pH 7.4），150 mM NaCl和0.05％叠氮化钠的缓冲液中。
蛋白G纯化
Preparation Note
自收到之日起，在2-8°C条件下可稳定保存1年。
Analysis Note
对照
人类阿尔茨海默病脑组织裂解物
人类阿尔茨海默病脑组织裂解物
通过蛋白质印迹法对人阿尔茨海默病脑组织裂解物进行评估。
蛋白质印迹分析：1 µg/ml的该抗体在10 µg人阿尔茨海默病脑组织裂解物中检测到淀粉样蛋白β42。
蛋白质印迹分析：1 µg/ml的该抗体在10 µg人阿尔茨海默病脑组织裂解物中检测到淀粉样蛋白β42。
Other Notes
浓度：请参考批次特异性浓缩物的检验报告。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
相关内容
Alzheimer’s Disease: Amyloid Cascade and Beyond Product Focus
Adriana Sofranko et al.
Particle and fibre toxicology, 19(1), 23-23 (2022-03-27)
There is an increasing concern about the neurotoxicity of engineered nanomaterials (NMs). To investigate the effects of subchronic oral exposures to SiO2 and CeO2 NMs on Alzheimer's disease (AD)-like pathology, 5xFAD transgenic mice and their C57BL/6J littermates were fed ad
Sophia Schedin-Weiss et al.
Alzheimer's research & therapy, 9(1), 57-57 (2017-08-03)
Increased levels of the pathogenic amyloid β-peptide (Aβ), released from its precursor by the transmembrane protease γ-secretase, are found in Alzheimer disease (AD) brains. Interestingly, monoamine oxidase B (MAO-B) activity is also increased in AD brain, but its role in
Tina Wahle et al.
Neurochemistry international, 138, 104755-104755 (2020-05-19)
Increasing evidence from toxicological and epidemiological studies indicates that the brain is an important target for ambient (ultrafine) particles. Disturbance of redox-homeostasis and inflammation in the brain are proposed as possible mechanisms that can contribute to neurotoxic and neurodegenerative effects.
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| MABN12 | 04053252726729 |