MABN2263
Anti-ZMYM2 Antibody, clone 9F12.1
clone 9F12.1, from mouse
别名:
Zinc finger MYM-type protein 2, Fused in myeloproliferative disorders protein, Rearranged in atypical myeloproliferative disorder protein, Zinc finger protein 198
生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified antibody
抗体产品类型
primary antibodies
克隆
9F12.1, monoclonal
种属反应性
human
包装
antibody small pack of 25 μg
技术
western blot: suitable
同位素/亚型
IgG2aκ
NCBI登记号
UniProt登记号
运输
ambient
靶向翻译后修饰
unmodified
基因信息
human ... ZMYM2(7750)
一般描述
Zinc finger MYM-type protein 2 (UniProt: Q9UBW7; also known as Fused in myeloproliferative disorders protein; Rearranged in atypical myeloproliferative disorder protein; Zinc finger protein 198) is encoded by the ZMYM2 (also known as FIM, RAMP, ZNF198) gene (Gene ID: 7750) in human. Zinc finger MYM-type protein 2 is a nuclear protein that may function as a transcription factor. Two isoforms of Zinc finger MYM-type protein 2 have been described that are produced by alternative splicing. The SUMO-interacting motifs (SIM) of Zinc finger MYM-type protein 2 are shown to be essential for its recruitment to chromatin. The SIM motifs play an important role in its gene-regulatory activities, however, they are not required for the intrinsic transcriptional repressive properties of Zinc finger MYM-type protein 2. A chromosomal aberration involving ZMYM2 is reported to cause stem cell leukemia lymphoma syndrome (SCLL), which is characterized as lymphoblastic lymphoma in association with a myeloproliferative disorder accompanied by pronounced peripheral eosinophilia and/or prominent eosinophilic infiltrates in the affected bone marrow. (Ref.: Aguilar-Martinez, E., et al. (2015). Proc. Natl. Acad. Sci. USA. 112 (35); E4854-E4863).
~155 kDa observed; 154.91 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
免疫原
GST/His-tagged recombinant fragment corresponding to 167 amino acids from the C-terminal region of human Zinc finger MYM-type protein 2.
应用
Anti-ZMYM2, clone 9F12.1, Cat. No. MABN2263, is a highly specific mouse monoclonal antibody that targets Zinc finger MYM-type protein 2 and has been tested in Western Blotting.
生化/生理作用
Clone 9F12.1 detects Zinc finger MYM-type protein 2 in human cells. It targets an epitope within 167 amino acids from the C-teminal region.
外形
Format: Purified
分析说明
Evaluated by Western Blotting in human hippocampus tissue lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected ZMYM2 in human hippocampus tissue lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected ZMYM2 in human hippocampus tissue lysate.
其他说明
Concentration: Please refer to lot specific datasheet.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
does not flash
闪点(°C)
does not flash
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