MABN238
胰高血糖素抗体，克隆13D11.33
clone 13D11.33, from mouse
别名:
4030-01F, 4031-01F, AB932
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
13D11.33, monoclonal
Application:
ELISA
immunofluorescence
immunohistochemistry
multiplexing
immunofluorescence
immunohistochemistry
multiplexing
Species reactivity:
human, rat
Citations:
11
Technique(s):
ELISA: suitable
immunofluorescence: suitable
immunohistochemistry: suitable (paraffin)
multiplexing: suitable
immunofluorescence: suitable
immunohistochemistry: suitable (paraffin)
multiplexing: suitable
Uniprot accession no.:
产品名称
胰高血糖素抗体，克隆13D11.33, clone 13D11.33, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
13D11.33, monoclonal
species reactivity
human, rat
technique(s)
ELISA: suitable
immunofluorescence: suitable
immunohistochemistry: suitable (paraffin)
multiplexing: suitable
isotype
IgG2bκ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... GCG(2641)
Analysis Note
对照
正常大鼠胰腺组织
正常大鼠胰腺组织
通过免疫荧光对正常大鼠胰腺组织进行了评估。
免疫荧光分析：该抗体的1:8,000稀释液在正常大鼠胰腺组织中检测到胰高血糖素。
免疫荧光分析：该抗体的1:8,000稀释液在正常大鼠胰腺组织中检测到胰高血糖素。
Application
免疫组化分析：代表性批次的1:8,000稀释液在正常大鼠胰腺组织中检测到胰高血糖素（为了增强染色结果，建议使用该抗体的10,000倍稀释液。）。
ELISA分析：代表性批次在ELISA中检测到胰高血糖素。
Luminex®分析：代表性批次在Luminex分析中检测到胰高血糖素。
ELISA分析：代表性批次在ELISA中检测到胰高血糖素。
Luminex®分析：代表性批次在Luminex分析中检测到胰高血糖素。
可使用这种胰高血糖素抗体（克隆13D11.33）检测胰高血糖素，该抗体经验证可用于IHC(P)、免疫荧光、ELISA和多重检测。
研究子类别
感官 & PNS
感官 & PNS
研究类别
神经科学
神经科学
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
胰高血糖素是一种激素，能被蛋白水解成至少八种不同功能的肽。它由胰腺细胞产生，在脑、肠道和肝脏等组织中有结合位点。胰高血糖素是低血糖时分泌的。通过Gsα-和Gq-偶联的跨膜受体及其下游信号通路的联合激活，胰高血糖素刺激葡萄糖从肝脏释放到血液中。这个过程的一个重要机制是蛋白激酶A（PKA）的激活。PKA信号导致磷酸烯醇丙酮酸羧激酶转录增加，该激酶编码非碳水化合物底物产生葡萄糖的限速酶。PKA信号也可能增加糖原的分解，抑制糖酵解。胰高血糖素还可能通过PLC参与钙依赖性信号传导。在II型糖尿病中胰高血糖素和胰高血糖素受体信号传导被破坏，这一发现突显了胰高血糖素与胰岛素在调节葡萄糖稳态中的重要性。
计算得出的分子量：21 kDa
Immunogen
卵清蛋白偶联线性肽，对应于人胰高血糖素。
Other Notes
浓度：请参考批次特异性浓缩物的检验报告。
Physical form
形式：纯化
纯化的小鼠单克隆IgG2aκ，溶于含有0.1 M Tris-甘氨酸（pH 7.4），150 mM NaCl和0.05％叠氮化钠的缓冲液中。
蛋白G纯化
Preparation Note
自收到之日起，在2-8°C条件下可稳定保存1年。
Legal Information
Luminex is a registered trademark of Luminex Corp
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Jing Liu et al.
Developmental cell, 48(1), 49-63 (2019-01-09)
In the developing pancreas, transient Neurog3-expressing progenitors give rise to four major islet cell types: α, β, δ, and γ; when and how the Neurog3+ cells choose cell fate is unknown. Using single-cell RNA-seq, trajectory analysis, and combinatorial lineage tracing
Karin J Bosma et al.
Molecular metabolism, 54, 101347-101347 (2021-10-10)
Type 2 diabetes is characterized by hyperglycemia and inflammation. Prostaglandin E2, which signals through four G protein-coupled receptors (EP1-4), is a mediator of inflammation and is upregulated in diabetes. We have shown previously that EP3 receptor blockade promotes β-cell proliferation
Peter A Kropp et al.
American journal of physiology. Endocrinology and metabolism, 314(4), E308-E321 (2018-01-20)
The transcription factors pancreatic and duodenal homeobox 1 (Pdx1) and onecut1 (Oc1) are coexpressed in multipotent pancreatic progenitors (MPCs), but their expression patterns diverge in hormone-expressing cells, with Oc1 expression being extinguished in the endocrine lineage and Pdx1 being maintained
Darian T Carroll et al.
Frontiers in endocrinology, 15, 1417437-1417437 (2024-08-08)
Using a non-human primate (NHP) model of maternal Western-style diet (mWSD) feeding during pregnancy and lactation, we previously reported altered offspring beta:alpha cell ratio in vivo and insulin hyper-secretion ex vivo. Mitochondria are known to maintain beta-cell function by producing
Chandan Sona et al.
JCI insight, 7(6) (2022-02-09)
BACKGROUNDPathophysiology of type 1 diabetes (T1D) is illustrated by pancreatic islet infiltration of inflammatory lymphocytes, including CD8+ T cells; however, the molecular factors mediating their recruitment remain unknown. We hypothesized that single-cell RNA-sequencing (scRNA-Seq) analysis of immune cell populations isolated
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