MABN2425
Anti-TRPV2 Antibody, clone 17A11
clone 17A11, from mouse
别名:
Transient receptor potential cation channel subfamily V member 2, Osm-9-like TRP channel 2, OTRPC2, Stretch-activated channel 2B, Vanilloid receptor-like protein 1, VRL-1
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
17A11, monoclonal
Application:
ICC, WB
Citations:
-
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
17A11, monoclonal
species reactivity
mouse, rat
packaging
antibody small pack of 25 μg
technique(s)
immunocytochemistry: suitable, western blot: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
target post-translational modification
unmodified
Gene Information
mouse ... Trpv2(22368)
rat ... Trpv2(29465)
General description
86.71 kDa calculated.
Transient receptor potential cation channel subfamily V member 2 (UniProt: Q9WUD2; also known as TrpV2, Osm-9-like TRP channel 2, OTRPC2, Stretch-activated channel 2B, Vanilloid receptor-like protein 1, VRL-1) is encoded by the Trpv2 (also known as Sac2b, Vrl1) gene (Gene ID: 29465) in rat. TrpV2 is an ubiquitously expressed, calcium-permeable, non-selective cation channel with an outward rectification. It has been implicated in various physiological and pathological processes, including growth factor signaling, macrophage migration, cancer cell metastasis, heart disease, and neuronal cell development. It appears to be regulated by growth factors, like IGF1, PDGF, and morphogenetic neuropeptide/head activator. It is also activated by temperatures higher than 52 degree C, but is not activated by vanilloids and acidic pH. TrpV2 channel is upregulated by the nerve growth factor (NGF) via the mitogen-activated protein kinase (MAPK) signaling pathway to augment neurite outgrowth. Although NGF increases TrpV2 content, it does not induce the translocation of TrpV2 from cytoplasm to cell surface in PC12 cells. (Ref.: Cohen MR., et al. (2015). Mol. Cell Biol. 35(24): 4238-4252).
Immunogen
1D4-tagged full length rat Transient receptor potential cation channel subfamily V member 2 (TRPV2).
Application
Anti-TRPV2, clone 17A11, Cat. No. MABN2425, is a highly specific mouse monoclonal antibody that targets TRPV2 and has been tested for use in Immunocytochemistry and Western Blotting.
Western Blotting Analysis: A representative lot detected TRPV2 in Western Blotting applications (Cohen, M.R., et. al. (2013). PLoS One. 8(12):e85392).
Immunocytochemistry Analysis: A representative lot detected TRPV2 in Immunocytochemistry applications (Cohen, M.R., et. al. (2013). PLoS One. 8(12):e85392; Cohen M.R., et. al. (2015). Mol Cell Biol. 35(24):4238-52).
Immunocytochemistry Analysis: A representative lot detected TRPV2 in Immunocytochemistry applications (Cohen, M.R., et. al. (2013). PLoS One. 8(12):e85392; Cohen M.R., et. al. (2015). Mol Cell Biol. 35(24):4238-52).
Biochem/physiol Actions
Clone 17A11 detects Transient receptor potential cation channel subfamily V member 2 (TRPV2) in mouse and rat cells.
Physical form
Format: Purified
Analysis Note
Evaluated by Immunocytochemistry in PC12 cells treated with NGF.
Immunocytochemistry Analysis: 2-10 µg/mL of this antibody detected TRPV2 in PC12 cells treated with mouse NGF.
Immunocytochemistry Analysis: 2-10 µg/mL of this antibody detected TRPV2 in PC12 cells treated with mouse NGF.
Other Notes
Concentration: Please refer to lot specific datasheet.
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