Beta-mannosidase, also known as Lysosomal beta A mannosidase or Mannanase, or Mannase, and encoded by the gene MANBA/MANB1, is an exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides. Beta-mannosidase is localized to the lysosome. Beta-mannosidase is expressed in many cell types including fibroblasts, neutrophils and even neurons and glia. Defects in Beta-mannosidase may be associated with a mild disorder that affects peripheral and central nervous system myelin health and is called Mannosidoisis beta A. It is a lysosomal storage disorder that results in a mixture of clinical features from mental retardation, hearing loss and speech activities.

KLH-conjugated linear peptide corresponding to human Beta-mannosidase.

Anti-Beta-mannosidase Antibody, clone 1B3.1 is a highly specific mouse monoclonal antibody, that targets Mannosidase & has been tested in western blotting & IHC (Paraffin).

Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected Beta-mannosidase in human cerebral cortex tissue.

Research Category
Neuroscience

Research Sub Category
Signaling Neuroscience

Evaluated by Western Blotting in HepG2 cell lysate.

Western Blotting Analysis: 0.2 µg/mL of this antibody detected Beta-mannosidase in 10 µg of HepG2 cell lysate.

~80 kDa observed. The calculated molecular weight of this protein is 100 kDa However, this protein undergoes post-translational modification, and may be observed at ~110 kDa, ~100 kDa, ~91 kDa, ~86 kDa, ~84 kDa, and ~75 kDa (Sopher, B. L., et al. (1993). Biochem J. 289(Pt 2):343-347.).

Protein G Purified

Format: Purified

Purified mouse monoclonal IgG1κ supernatant in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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