MABN293
Anti-Peripherin-2 Antibody, clone 6B10.1
clone 6B10.1, from mouse
别名:
Peripherin-2, Retinal degeneration slow protein, Tetraspanin-22, Tspan-22
产品名称
Anti-Peripherin-2 Antibody, clone 6B10.1, clone 6B10.1, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
6B10.1, monoclonal
species reactivity
mouse, rat, human
technique(s)
immunohistochemistry: suitable
western blot: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... PRPH2(5961)
Physical form
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Evaluated by Western Blotting in mouse eye tissue lysate.
Western Blotting Analysis: A 1:1,000 dilution of this antibody detected Peripherin-2 in 10 µg of mouse eye tissue lysate.
Western Blotting Analysis: A 1:1,000 dilution of this antibody detected Peripherin-2 in 10 µg of mouse eye tissue lysate.
Application
Anti-Peripherin-2 Antibody, clone 6B10.1 is a highly specific mouse monoclonal antibody, that targets Peripherin & has been tested in western blotting & IHC.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Developmental Signaling
Developmental Signaling
Western Blotting Analysis: A 1:1,000 dilution from a representative lot detected Peripherin-2 in 10 µg of human retina tissue lysate.
Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected Peripherin-2 in human retina tissue.
Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected Peripherin-2 in human retina tissue.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Peripherin-2 (PRPH2) is also called Retinal degeneration slow protein (RDS) and Tetraspanin-22 (Tspan-22). Peripherin-2 is a critical factor in ocular disk morphogenesis and possibly functions as an adhesion molecule helping to stabilize and compact outer segment disks, to help maintain curvature of the rim. Peripherin-2 is expressed in the photoreceptors of the retina and in the rim of rod outer segment (ROS) disks. Peripherin-2 defects are found in different retinal diseases including cone-rod dystrophy, retinitis pigmentosa, and macular degeneration.
~35 kDa observed
Immunogen
Epitope: Cytoplasmic domain
GST-tagged recombinant protein corresponding to the cytoplasmic domain of human Peripherin-2.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Kai Yao et al.
Nature, 560(7719), 484-488 (2018-08-17)
In zebrafish, Müller glia (MG) are a source of retinal stem cells that can replenish damaged retinal neurons and restore vision1. In mammals, however, MG do not spontaneously re-enter the cell cycle to generate a population of stem or progenitor
Tylor R Lewis et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 41(16), 3588-3596 (2021-03-13)
Mutations in the PRPH2 gene encoding the photoreceptor-specific protein PRPH2 (also known as peripherin-2 or rds) cause a broad range of autosomal dominant retinal diseases. Most of these mutations affect the structure of the light-sensitive photoreceptor outer segment, which is
Katie L Bales et al.
Investigative ophthalmology & visual science, 61(10), 17-17 (2020-08-11)
To identify the role of the BBSome protein Bardet-Biedl syndrome 5 (BBS5) in photoreceptor function, protein trafficking, and structure using a congenital mutant mouse model. Bbs5-/- mice (2 and 9 months old) were used to assess retinal function and morphology.
Suguru Yamasaki et al.
iScience, 25(1), 103657-103657 (2022-01-14)
Pluripotent stem cell (PSC)-derived retinal sheet transplanted in vivo can form structured photoreceptor layers, contact with host bipolar cells, and transmit light signals to host retinas. However, a major concern is the presence of graft bipolar cells that may impede host-graft
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