MABN478
Anti-Spred-1 Antibody, clone M23-P2G3
clone M23-P2G3, from mouse, purified by affinity chromatography
别名:
Sprouty-related, EVH1 domain-containing protein 1, Spred-1, hSpred1
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
M23-P2G3, monoclonal
Application:
ICC, WB
Citations:
-
biological source
mouse
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
M23-P2G3, monoclonal
purified by
affinity chromatography
species reactivity
rat, mouse
species reactivity (predicted by homology)
human (based on 100% sequence homology)
technique(s)
immunocytochemistry: suitable, western blot: suitable
isotype
IgG1λ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SPRED1(161742)
General description
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) is a tyrosine kinase substrate which has a cysteine-rich domain which resembles the SPR domain at the carboxy terminus. SPRED1 associated with Ras blocks phosphorylation of Raf and disrupts MAP kinase signaling during the differentiation of neuronal cells and myocytes. A mutation in SPRED1 has been linked to Lugius syndrome, an autosomal dominant RAS-MAPK pathway syndrome.
~ 60 kDa observed
Immunogen
Linear peptide corresponding to human Spred-1.
Application
Detect Spred-1 using this mouse monoclonal antibody, Anti-Spred-1 Antibody, clone M23-P2G3 validated for use in western blotting & ICC.
Immunocytochemistry Analysis: A representative lot detected Spred-1 in HeLa cells.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Developmental Signaling
Developmental Signaling
Physical form
Protein G Purified
Purified mouse monoclonal IgG1λ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Evaluated by Western Blotting in mouse brain tissue lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected Spred-1 in 10 µg of mouse brain tissue lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected Spred-1 in 10 µg of mouse brain tissue lysate.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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