MABN504
抗VDAC1 抗体，克隆 N152B/23
clone N152B/23, from mouse
别名:
Voltage-dependent anion-selective channel protein 1, VDAC-1, hVDAC1, Outer mitochondrial membrane protein porin 1, Plasmalemmal porin, Porin 31HL, Porin 31HM
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
N152B/23, monoclonal
Application:
IHC, WB
Citations:
29
biological source
mouse
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
N152B/23, monoclonal
species reactivity
rat, mouse, human
packaging
antibody small pack of 25 μg
technique(s)
immunohistochemistry: suitable, western blot: suitable
isotype
IgG2aκ
NCBI accession no.
UniProt accession no.
shipped in
ambient
storage temp.
2-8°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... VDAC1(7416)
General description
可观察到约35 kDa的条带
电压依赖性阴离子选择性通道蛋白1（VDAC1，VDAC），也称为线粒体外膜蛋白孔蛋白1，是己糖激酶和BCL2L1的线粒体外膜受体。VDAC1可形成通过线粒体膜的通道，并参与小分子扩散、细胞体积调节和细胞凋亡。VDAC1可能参与渗透性转换孔复合物（PTPC）的形成，该复合物负责线粒体产物的释放，从而触发细胞凋亡。
Immunogen
对应于人VDAC1的重组蛋白。
Application
使用此小鼠单克隆抗体，抗VDAC1抗体，克隆N152B/23，检测VDAC，其已经过验证可用于蛋白质印迹和&IHC。
研究子类别
发育信号转导
发育信号转导
研究类别
神经科学
神经科学
蛋白印迹分析: 代表性批次产品表明VDAC1不与VDAC2或VDAC3发生交叉反应（基于KO验证结果）。代表性批次产品在野生型小鼠肝组织中检测到VDAC1，并使用免疫印迹分析证实了VDAC1敲除小鼠海马组织中的信号丢失（J. Trimmer教授，加州大学戴维斯分校）。
免疫组织化学分析：一个代表性批次产品以1：250的稀释度在人心肌细胞组织中检测到VDAC1。
免疫组织化学分析：一个代表性批次产品以1：250的稀释度在人心肌细胞组织中检测到VDAC1。
Biochem/physiol Actions
该抗体不会与VDAC2或VDAC3发生交叉反应（J. Trimmer教授，加州大学戴维斯分校）。
Physical form
形式：纯化
纯化的小鼠单克隆IgG2aκ，溶于含有0.1 M Tris-甘氨酸（pH 7.4，150 mM NaCl）和0.05％叠氮化钠的缓冲液中。
蛋白G纯化
Preparation Note
自发运之日起，在 2-8°C 条件下可稳定保存1年
Analysis Note
对照
小鼠脑组织裂解液
小鼠脑组织裂解液
通过蛋白质印迹在小鼠脑组织裂解液中进行了评估。
蛋白质印迹分析：0.5 µg/mL的该抗体可在10 µg小鼠脑组织裂解物中检测到VDAC1。
蛋白质印迹分析：0.5 µg/mL的该抗体可在10 µg小鼠脑组织裂解物中检测到VDAC1。
Other Notes
浓度：请参考批次特异性浓缩物的分析证书。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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