MABN504
抗VDAC1 抗体，克隆 N152B/23
clone N152B/23, from mouse
别名:
Voltage-dependent anion-selective channel protein 1, VDAC-1, hVDAC1, Outer mitochondrial membrane protein porin 1, Plasmalemmal porin, Porin 31HL, Porin 31HM
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
N152B/23, monoclonal
Application:
immunohistochemistry
western blot
western blot
Species reactivity:
rat, mouse, human
Citations:
30
Technique(s):
immunohistochemistry: suitable
western blot: suitable
western blot: suitable
Uniprot accession no.:
产品名称
抗VDAC1 抗体，克隆 N152B/23, clone N152B/23, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
N152B/23, monoclonal
species reactivity
rat, mouse, human
packaging
antibody small pack of 25 μg
technique(s)
immunohistochemistry: suitable
western blot: suitable
isotype
IgG2aκ
NCBI accession no.
UniProt accession no.
shipped in
ambient
storage temp.
2-8°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... VDAC1(7416)
Analysis Note
对照
小鼠脑组织裂解液
小鼠脑组织裂解液
通过蛋白质印迹在小鼠脑组织裂解液中进行了评估。
蛋白质印迹分析：0.5 µg/mL的该抗体可在10 µg小鼠脑组织裂解物中检测到VDAC1。
蛋白质印迹分析：0.5 µg/mL的该抗体可在10 µg小鼠脑组织裂解物中检测到VDAC1。
Application
使用此小鼠单克隆抗体，抗VDAC1抗体，克隆N152B/23，检测VDAC，其已经过验证可用于蛋白质印迹和&IHC。
研究子类别
发育信号转导
发育信号转导
研究类别
神经科学
神经科学
蛋白印迹分析: 代表性批次产品表明VDAC1不与VDAC2或VDAC3发生交叉反应（基于KO验证结果）。代表性批次产品在野生型小鼠肝组织中检测到VDAC1，并使用免疫印迹分析证实了VDAC1敲除小鼠海马组织中的信号丢失（J. Trimmer教授，加州大学戴维斯分校）。
免疫组织化学分析：一个代表性批次产品以1：250的稀释度在人心肌细胞组织中检测到VDAC1。
免疫组织化学分析：一个代表性批次产品以1：250的稀释度在人心肌细胞组织中检测到VDAC1。
Biochem/physiol Actions
该抗体不会与VDAC2或VDAC3发生交叉反应（J. Trimmer教授，加州大学戴维斯分校）。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
可观察到约35 kDa的条带
电压依赖性阴离子选择性通道蛋白1（VDAC1，VDAC），也称为线粒体外膜蛋白孔蛋白1，是己糖激酶和BCL2L1的线粒体外膜受体。VDAC1可形成通过线粒体膜的通道，并参与小分子扩散、细胞体积调节和细胞凋亡。VDAC1可能参与渗透性转换孔复合物（PTPC）的形成，该复合物负责线粒体产物的释放，从而触发细胞凋亡。
Immunogen
对应于人VDAC1的重组蛋白。
Other Notes
浓度：请参考批次特异性浓缩物的分析证书。
Physical form
形式：纯化
纯化的小鼠单克隆IgG2aκ，溶于含有0.1 M Tris-甘氨酸（pH 7.4，150 mM NaCl）和0.05％叠氮化钠的缓冲液中。
蛋白G纯化
Preparation Note
自发运之日起，在 2-8°C 条件下可稳定保存1年
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Maria Feola et al.
Communications biology, 4(1), 517-517 (2021-05-05)
Erythropoiesis involves complex interrelated molecular signals influencing cell survival, differentiation, and enucleation. Diseases associated with ineffective erythropoiesis, such as β-thalassemias, exhibit erythroid expansion and defective enucleation. Clear mechanistic determinants of what make erythropoiesis effective are lacking. We previously demonstrated that
Abdulhafiz D Imam Aliagan et al.
American journal of translational research, 12(11), 7542-7564 (2020-12-15)
Mitochondrial dysfunction plays a critical role in the pathophysiology of Parkinson's disease (PD). The inner mitochondrial membrane (IMM) protein, Mitofilin or Mic60, has been shown to play a key role in controlling and maintaining mitochondrial cristae morphology, and its dysregulation
Ngonidzashe B Madungwe et al.
American journal of translational research, 12(7), 3412-3428 (2020-08-11)
MPV17 is an inner mitochondrial membrane protein whose mutation results in mitochondrial DNA (mtDNA) depletion diseases such as neurohepatopathy. MPV17 is expressed in several organs including the liver and kidneys. Here, we investigated its role and mechanism of action in
Mitofilin Heterozygote Mice Display an Increase in Myocardial Injury and Inflammation after Ischemia/Reperfusion.
Feng, et al.
Antioxidants (Basel, Switzerland), 12 (2023)
Gui-Ying Yao et al.
Cell death & disease, 9(10), 1033-1033 (2018-10-12)
Ischemic postconditioning provides robust neuroprotection, therefore, determining the molecular events may provide promising targets for stroke treatment. Here, we showed that the expression of functional mitochondrial voltage-dependent anion channel proteins (VDAC1, VDAC2, and VDAC3) reduced in rat vulnerable hippocampal CA1
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