MABN763
Anti-Ubiquilin 2 Antibody, clone 6H9
clone 6H9, from mouse
别名:
Ubiquilin-2, Chap1, DSK2 homolog, Protein linking IAP with cytoskeleton 2, PLIC-2, hPLIC-2, Ubiquitin-like product Chap1/Dsk2
产品名称
Anti-Ubiquilin 2 Antibody, clone 6H9, clone 6H9, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
6H9, monoclonal
species reactivity
human, mouse
technique(s)
immunocytochemistry: suitable
western blot: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... UBQLN2(29978)
Analysis Note
Evaluated by Western Blotting in U-251 cell lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected Ubiquilin 2 in 10 µg of U-251 cell lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected Ubiquilin 2 in 10 µg of U-251 cell lysate.
Application
Detect Ubiquilin-2 using this mouse monoclonal antibody, Anti-Ubiquilin 2 Antibody, clone 6H9 validated for use in western blotting & ICC.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Developmental Signaling
Developmental Signaling
Western Blotting Analysis: 1.0 µg/mL from a representative lot detected Ubiquilin 2 in 10 µg of SH-SY5Y and NIH-3T3 cell lysate.
Immunocytochemistry Analysis: A representative lot detected Ubiquilin 2 in HeLa cells.
Immunocytochemistry Analysis: A representative lot detected Ubiquilin 2 in HeLa cells.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Ubiquilin-2, also known as Chap1, DSK2 homolog, Protein linking IAP with cytoskeleton 2 (PLIC-2 or hPLIC-2), Ubiquitin-like product Chap1/Dsk2, and encoded by the gene UBQLN2/N4BP4/PLIC2, is a protein that appears to modulate the half-life of proteins destined to be degraded by the proteasome. Ubiquilin 2 binds UBE3A and BTRC ubquitin ligases and interacts with the 19S proteasome subunit to mediate its activity. Ubiquilin 2 is localized to the cytoplasm and nucleus, and colocalizes with proteasome. Ubiquilin 2 is expressed in mitotic cells very strongly; expression is low in non-dividing cells. Defects in Ubiquilin 2 may be associated with ALS form 15 a neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis.
~66 kDa observed
Immunogen
Recombinant protein corresponding to human Ubiquilin 2.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Physical form
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ in buffer containing PBS, 50% glycerol, and 0.05% sodium azide.
Preparation Note
Stable for 1 year at -20°C from date of receipt.
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存储类别
10 - Combustible liquids
wgk
WGK 2
Oscar Jara et al.
Molecular vision, 26, 204-215 (2020-03-28)
p62/Sequestosome 1 (p62) is a stress-induced protein that is involved in several different intracellular pathways, including regulation of aspects of protein degradation. p62 levels are elevated in several types of cataracts. We investigated whether levels of p62 and its phosphorylation
Aya Jodo et al.
Frontiers in immunology, 11, 1559-1559 (2020-08-28)
Activation of NF-κB transcription factors is critical for innate immune cells to induce inflammation and fight against microbial pathogens. On the other hand, the excessive and prolonged activation of NF-κB causes massive inflammatory damage to the host, suggesting that regulatory
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