MABS409
Anti-NFATc1 Antibody, clone 7A6
clone 7A6, from mouse
别名:
Nuclear factor of activated T-cells, cytoplasmic 1, NF-ATc1, NFATc1, NFAT transcription complex cytosolic component, NF-Atc, NFATc
生物来源
mouse
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
7A6, monoclonal
种属反应性
human, mouse
技术
flow cytometry: suitable
immunofluorescence: suitable
western blot: suitable
同位素/亚型
IgG1
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... NFATC1(4772)
一般描述
NFATc1, also known as Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1, is a component of the nuclear factor of activated T cells DNA-binding transcription complex which consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. This protein plays a main role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription and functions as a major molecular target for the immunosuppressive drugs such as cyclosporine A. NFATc1 is expressed in most human primary lymphocytes and mature human T- and B-cell neoplasms.
~~95, ~110 and ~130 kDa observed
免疫原
Recombinant protein of human NFATc1 amino acids 197-304
应用
Detect NFAT using this mouse monoclonal antibody, Anti-NFATc1 Antibody, clone 7A6 validated for use in western blotting, Flow Cytometry & Immunofluorescence.
Flow Cytometry Analysis: A representative lot detected human NFATc1 in Flow Cytometry. (Brandt C, et al. 2010.)
Immunofluorescent Analysis: A representative lot detected human NFATc1 in Immunofluorescence. (Timmerman LA, et al. 1997.)
Immunofluorescent Analysis: A representative lot detected human NFATc1 in Immunofluorescence. (Timmerman LA, et al. 1997.)
外形
Format: Purified
Purified mouse monoclonal IgG1 antibody in buffer containing PBS (pH 7.2) with up to 0.1% sodium azide.
制备说明
The antibody solution should be stored undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.
分析说明
Evaluated by Western Blotting in Jurkat, human Th1, and mouse Th1 cell extracts.
Western Blotting Analysis: 1 μg/mL of this antibody detected in Jurkat, human Th1, and mouse Th1 cell extracts.
Western Blotting Analysis: 1 μg/mL of this antibody detected in Jurkat, human Th1, and mouse Th1 cell extracts.
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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