生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified antibody
抗体产品类型
primary antibodies
克隆
3G5.1, monoclonal
种属反应性
rat
种属反应性（根据同源性预测）
mouse (based on 100% sequence homology), Xenopus (based on 100% sequence homology), human (based on 100% sequence homology), porcine (based on 100% sequence homology), chicken (based on 100% sequence homology), bovine (based on 100% sequence homology)
技术
western blot: suitable
同位素/亚型
IgG1κ
NCBI登记号
UniProt登记号
靶向翻译后修饰
unmodified
基因信息
human ... RPS6KA1(6195)
一般描述
Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1; UniProt Q15418; also known as 90 kDa ribosomal protein S6 kinase 1, MAP kinase-activated protein kinase 1a, MAPK-activated protein kinase 1a, MAPKAP kinase 1a, MAPKAPK-1a, p90-RSK 1, p90RSK1, p90S6K, Ribosomal S6 kinase 1, RSK-1, S6K-alpha-1) is encoded by the RPS6KA1 (also known as MAPKAPK1A, RSK1) gene (Gene ID 6195) in human. Ribosomal s6 kinases (RSKs) are serine/threonine kinases that play a role in mediating Mek1/2-Erk1/2 mitogen-activated protein (MAP) kinase pathway signaling events. There exist two types of RSKs, p70rsk (a.k.a. S6 Kinase or S6-H1 kinase) and p90rsk (a.k.a. MAPK-activated protein kinase). Six p90rsk-coding genes have been identified in human, RPS6KA1 (MAPKAPK1A, RSK1), RPS6KA2 (MAPKAPK1C, RSK3), RPS6KA3 (MAPKAPK1B, RSK2), RPS6KA4 (MSK2), RPS6KA5 (MSK1), and RPS6KA6 (RSK4). p90RSK1 is activated by sequential phosphorylation events, where it is first phosphorylated by Erk1/2 on the C-terminal kinase domain (CTKD) Thr573, leading to subsequent Ser380 phosphorylation in the N-terminal AGC kinase-type domain. Alternatively, Ser380 can be phosphorylated directly by MK2/3 independent of CTKD Thr573 phosphorylation.
特异性
Clone 3G5.1 target epitope sequence is present in all four human Rsk1 spliced isoforms reported by UniProt (Q15418).
免疫原
Epitope: Linker region between two kinase domains.
KLH-conjugated linear peptide corresponding to a sequence from the linker region between the two human Rsk1 kinase domains.
应用
Anti-Rsk1 Antibody, clone 3G5.1 is an antibody against Rsk1 for use in Western Blotting.
质量
Evaluated by Western Blotting in PC12 cell lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected Rsk1 in 10 µg of PC12 rat pheochromocytoma cell lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected Rsk1 in 10 µg of PC12 rat pheochromocytoma cell lysate.
目标描述
~85 kDa observed. 82.88 kDa (rat), 86.47 kDa (mouse), 82.72 kDa (human isoform 1), 83.93 kDa (human isoform 2), 72.70 kDa (human isoform 3), and 81.15 kDa (human isoform 4) calculated. Uncharacterized band(s) may appear in some lysates.
外形
Format: Purified
其他说明
Concentration: Please refer to lot specific datasheet.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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