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Merck
CN

MABS826

Anti-Rsk1 Antibody, clone 3G5.1

clone 3G5.1, from mouse

别名:

Ribosomal protein S6 kinase alpha-1, 90 kDa ribosomal protein S6 kinase 1, MAP kinase-activated protein kinase 1a, MAPK-activated protein kinase 1a, MAPKAP kinase 1a, MAPKAPK-1a, p90-RSK 1, p90RSK1, p90S6K, Ribosomal S6 kinase 1, RSK-1, S6K-alpha-1

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

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产品名称

Anti-Rsk1 Antibody, clone 3G5.1, clone 3G5.1, from mouse

biological source

mouse

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

3G5.1, monoclonal

species reactivity

rat

species reactivity (predicted by homology)

mouse (based on 100% sequence homology), Xenopus (based on 100% sequence homology), human (based on 100% sequence homology), porcine (based on 100% sequence homology), chicken (based on 100% sequence homology), bovine (based on 100% sequence homology)

technique(s)

western blot: suitable

isotype

IgG1κ

NCBI accession no.

NP_002944

UniProt accession no.

Q15418

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... RPS6KA1(6195)

Analysis Note

Evaluated by Western Blotting in PC12 cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Rsk1 in 10 µg of PC12 rat pheochromocytoma cell lysate.

Application

Anti-Rsk1 Antibody, clone 3G5.1 is an antibody against Rsk1 for use in Western Blotting.

Biochem/physiol Actions

Clone 3G5.1 target epitope sequence is present in all four human Rsk1 spliced isoforms reported by UniProt (Q15418).

General description

Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1; UniProt Q15418; also known as 90 kDa ribosomal protein S6 kinase 1, MAP kinase-activated protein kinase 1a, MAPK-activated protein kinase 1a, MAPKAP kinase 1a, MAPKAPK-1a, p90-RSK 1, p90RSK1, p90S6K, Ribosomal S6 kinase 1, RSK-1, S6K-alpha-1) is encoded by the RPS6KA1 (also known as MAPKAPK1A, RSK1) gene (Gene ID 6195) in human. Ribosomal s6 kinases (RSKs) are serine/threonine kinases that play a role in mediating Mek1/2-Erk1/2 mitogen-activated protein (MAP) kinase pathway signaling events. There exist two types of RSKs, p70rsk (a.k.a. S6 Kinase or S6-H1 kinase) and p90rsk (a.k.a. MAPK-activated protein kinase). Six p90rsk-coding genes have been identified in human, RPS6KA1 (MAPKAPK1A, RSK1), RPS6KA2 (MAPKAPK1C, RSK3), RPS6KA3 (MAPKAPK1B, RSK2), RPS6KA4 (MSK2), RPS6KA5 (MSK1), and RPS6KA6 (RSK4). p90RSK1 is activated by sequential phosphorylation events, where it is first phosphorylated by Erk1/2 on the C-terminal kinase domain (CTKD) Thr573, leading to subsequent Ser380 phosphorylation in the N-terminal AGC kinase-type domain. Alternatively, Ser380 can be phosphorylated directly by MK2/3 independent of CTKD Thr573 phosphorylation.
~85 kDa observed. 82.88 kDa (rat), 86.47 kDa (mouse), 82.72 kDa (human isoform 1), 83.93 kDa (human isoform 2), 72.70 kDa (human isoform 3), and 81.15 kDa (human isoform 4) calculated. Uncharacterized band(s) may appear in some lysates.

Immunogen

Epitope: Linker region between two kinase domains.
KLH-conjugated linear peptide corresponding to a sequence from the linker region between the two human Rsk1 kinase domains.

Other Notes

Concentration: Please refer to lot specific datasheet.

Physical form

Format: Purified

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存储类别

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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