MABT106
Anti-Protein Spindly Antibody, clone 9D10.2
clone 9D10.2, from mouse
别名:
Protein Spindly, hSpindly, Arsenite-related gene 1 protein, Coiled-coil domain-containing protein 99, Rhabdomyosarcoma antigen MU-RMS-40.4A
产品名称
Anti-Protein Spindly Antibody, clone 9D10.2, clone 9D10.2, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
9D10.2, monoclonal
species reactivity
human, mouse
technique(s)
immunocytochemistry: suitable
western blot: suitable
isotype
IgMκ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SPDL1(54908)
Analysis Note
Control
HEK293 cell lysate
HEK293 cell lysate
Evaluated by Western Blot in HEK293 cell lysate.
Western Blot Analysis: 0.1 µg/mL of this antibody detected Protein Spindly in 10 µg of HEK293 cell lysate.
Western Blot Analysis: 0.1 µg/mL of this antibody detected Protein Spindly in 10 µg of HEK293 cell lysate.
Application
Detect Protein Spindly using this Anti-Protein Spindly Antibody, clone 9D10.2 validated for use in ICC, Western Blotting.
Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected Protein Spindly in HeLa and NIH/3T3.
Research Category
Cell Structure
Cell Structure
Research Sub Category
Cytoskeleton
Cytoskeleton
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Protein spindly, otherwise known as the coiled-coil domain-containing protein 99 (CCDC99), is a phosphoprotein that regulates mitosis. It interacts with the Rod/ZW10/Zwilch complex, and is involved in recruiting, docking, and alignment of motor protein dynein at mitotic kinetochores. Spindly may also be involved in checkpoint signaling and microtubule attachment.
~70 kDa observed. This protein is known to exist in two isoforms at 70 kDa and 56 kDa An uncharacterized band may be observed at ~38 kDa in some cell lysates.
Immunogen
GST-tagged recombinant protein corresponding to human Protein Spindly.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Physical form
Format: Purified
Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Bingteng Xie et al.
Cell research, 28(4), 462-475 (2018-02-22)
Before fertilization, mammalian oocyte undergoes an asymmetric division which depends on eccentric positioning of the spindle at the oocyte cortex to form a polar body and an egg. Since the centriole is absent and, as a result, the polar array
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