MABT20
Anti-OL-protocadherin Antibody, clone 5G10
clone 5G10, from rat
别名:
protocadherin 10, ortholog of OL-pcdh
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
5G10, monoclonal
Application:
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Species reactivity:
mouse
Citations:
9
Technique(s):
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
immunohistochemistry: suitable
western blot: suitable
Uniprot accession no.:
产品名称
Anti-OL-protocadherin Antibody, clone 5G10, clone 5G10, from rat
biological source
rat
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
5G10, monoclonal
species reactivity
mouse
technique(s)
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
isotype
IgG2aκ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
mouse ... Pcdh10(18526)
Analysis Note
Control
Mouse E13-E14 brain tissue lysate
Mouse E13-E14 brain tissue lysate
Evaluated by Western Blot in mouse E13-E14 brain tissue lysate.
Western Blot Analysis: 1 µg/mL of the antibody detected OL-protocadherin in 10 µg of mouse E13-E14 brain tissue lysate.
Western Blot Analysis: 1 µg/mL of the antibody detected OL-protocadherin in 10 µg of mouse E13-E14 brain tissue lysate.
Application
Anti-OL-protocadherin Antibody, clone 5G10 is an antibody against OL-protocadherin for use in WB, IC, IH.
Immunofluorescence Analysis: The antibody has been shown to detect OL-protocadherin in IF. (Nakao, 2008).
Immunohistochemistry Analysis: The antibody has been shown to detect OL-protocadherin in IH. (Aoki, 2003).
Immunohistochemistry Analysis: The antibody has been shown to detect OL-protocadherin in IH. (Aoki, 2003).
Research Category
Cell Structure
Neuroscience
Cell Structure
Neuroscience
Research Sub Category
Adhesion (CAMs)
Synapse & Synaptic Biology
Adhesion (CAMs)
Synapse & Synaptic Biology
Biochem/physiol Actions
The antibody recognizes the cytoplasmic domain of OL-protocadherin.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
OL-protocadherin (OL-pc, protocadherin 10) is a transmembrane protein and a member of the cadherin superfamily, which is characterized by its members’ abilities to undergo interactions that are homophilic in nature via their extracellular domain. Several protocadherins have been observed within the nervous system, and a few have been shown to localize at synapses. With OL-pc, the homophilic binding has been shown to stimulate cell aggregation when the protein is introduced into cadherin-deficient cells. Although the function of OL-protocadherin has yet to be elucidated, studies have shown OL-pc to be necessary to axonal normal projection through the ventral telencephalon, where OL-pc shows highest expression at the striatal region.
~ 130 kDa observed
Immunogen
Epitope: Cytoplasmic domain
GST-tagged recombinant protein corresponding to the cytoplasmic domain of mouse OL-protocadherin.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Physical form
Format: Purified
Protein G Purified
Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine, pH 7.4, 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Yuanjun Luo et al.
Scientific reports, 13(1), 7114-7114 (2023-05-03)
The olivocerebellar projection is organized into an intricate topographical connection from the inferior olive (IO) subdivisions to the longitudinally-striped compartments of cerebellar Purkinje Cells (PCs), to play an essential role in cerebellar coordination and learning. However, the central mechanisms for
Khoa Tran-Anh et al.
eNeuro, 7(6) (2020-10-16)
One of the notable characteristics of the functional localization in the cerebellar cortex is the dual representation of the body (somatotopy) on its anterior-posterior axis. This somatotopy is conspicuous in the C1/C3 module, which is demarcated as the multiple zebrin-negative
Clustered fine compartmentalization of the mouse embryonic cerebellar cortex and its rearrangement into the postnatal striped configuration.
Fujita, H; Morita, N; Furuichi, T; Sugihara, I
The Journal of Neuroscience null
Joyce M Hoek et al.
PeerJ, 8, e9300-e9300 (2020-06-18)
Despite the widespread use of antibodies as a research tool, problems with specificity, lot-to-lot consistency and sensitivity commonly occur and may be important contributing factors to the 'replication crisis' in biomedical research. This makes the validation of antibodies and accurate
Suteera Vibulyaseck et al.
The Journal of comparative neurology, 525(14), 2971-2990 (2017-05-26)
Transversely oriented lobules and longitudinally arrayed stripes of Purkinje cell subsets subdivide the cerebellar cortex into multiple compartments that are involved in diverse functions. In the mammalian cerebellum, anterior, and posterior lobules, which are involved in somatosensorimotor function, show an
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