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Merck
CN

MABT419

Anti-CD2AP Antibody, clone 2A2.1

clone 2A2.1, from mouse

别名:

CD2-associated protein, CD2AP, Adapter protein CMS, Cas ligand with multiple SH3 domains

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
2A2.1, monoclonal
Application:
immunohistochemistry
western blot
Species reactivity:
human
Citations:
1
Technique(s):
immunohistochemistry: suitable (paraffin)
western blot: suitable
Uniprot accession no.:
Q9Y5K6

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产品名称

Anti-CD2AP Antibody, clone 2A2.1, clone 2A2.1, from mouse

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

2A2.1, monoclonal

species reactivity

human

technique(s)

immunohistochemistry: suitable (paraffin)
western blot: suitable

isotype

IgG1κ

NCBI accession no.

NP_036252

UniProt accession no.

Q9Y5K6

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... CD2AP(23607)

Analysis Note

Evaluated by Western Blotting in Raji cell lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected CD2AP in 10 µg of Raji cell lysate.

Application

Immunohistochemistry Analysis: A 1:250-1,000 dilution from a representative lot detected CD2AP in human kidney and human colon tissue.
This Anti-CD2AP Antibody, clone 2A2.1 is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of CD2AP.

General description

CD2-associated protein (UniProt Q9Y5K6; also known as Adapter protein CMS, Cas ligand with multiple SH3 domains) is encoded by the CD2AP (also known as CMS) gene (Gene ID 23607) in human. CD2AP is an adapter protein expressed in all tissues except brain. CD2AP harbors three SH3 domains at its N-terminal, a proline-rich domain, and a C-terminal leucine-zipper domain that mediates CD2AP homodimerization. CD2AP is known to interact with actin-associated proteins, such as cortactin, and actin capping protein CAPZ. The SH3 domains of CD2AP mediate its association to the hypervariable C terminal region of Rac1, allowing CD2AP to act as a linker between Rac1 and the actin-binding proteins cortactin and CAPZ. CD2AP also plays an important role in the formation of the slit diaphragm in the kidney glomerulus between podocyte foot processes by linking the cell-cell adhesion protein nephrin to the cytoskeleton. CD2AP gene mutations are associated with kidney diseases such as sporadic nephrotic syndrome and focal segmental glomerulosclerosis.
~71 kDa observed

Immunogen

GST-tagged recombinant protein corresponding to the C-terminal half of human CD2AP.

Other Notes

Concentration: Please refer to lot specific datasheet.

Physical form

Format: Purified

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存储类别

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Timothy D Cummins et al.
Journal of cell science, 131(1) (2017-11-28)
Our previous studies of PAWS1 (protein associated with SMAD1; also known as FAM83G) have suggested that this molecule has roles beyond BMP signalling. To investigate these roles, we have used CRISPR/Cas9 to generate PAWS1-knockout U2OS osteosarcoma cells. Here, we show

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