MABT827-AF555
Anti-Dystrophin Antibody, clone 2C6 (MANDYS106), Alexa Fluor™ 555 Conjugate
clone 2C6 (MANDYS106), from mouse, ALEXA FLUOR™ 555
别名:
Dystrophin
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关于此项目
eCl@ss:
32160702
UNSPSC Code:
12352203
Conjugate:
ALEXA FLUOR™ 555
Clone:
2C6 (MANDYS106), monoclonal
Application:
immunofluorescence
Species reactivity:
human
Citations:
Technique(s):
immunofluorescence: suitable
Uniprot accession no.:
产品名称
Anti-Dystrophin Antibody, clone 2C6 (MANDYS106), Alexa Fluor™ 555 Conjugate, clone 2C6 (MANDYS106), from mouse, ALEXA FLUOR™ 555
biological source
mouse
conjugate
ALEXA FLUOR™ 555
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
2C6 (MANDYS106), monoclonal
species reactivity
human
technique(s)
immunofluorescence: suitable
isotype
IgG2aκ
NCBI accession no.
UniProt accession no.
shipped in
ambient
target post-translational modification
unmodified
Quality Level
Gene Information
human ... DMD(1756)
Analysis Note
Control
The unconjugated antibody (Cat. No. MABT827) and Alexa Fluor™ 488 conjugate (Cat. No. MABT827-AF488) are also available for Immunohistochemistry
Immunofluorescence
and Western Blotting applications.
The unconjugated antibody (Cat. No. MABT827) and Alexa Fluor™ 488 conjugate (Cat. No. MABT827-AF488) are also available for Immunohistochemistry
Immunofluorescence
and Western Blotting applications.
Evaluated by Immunofluorescence in human skeletal muscle tissue sections.
Immunofluorescence Analysis: A 1:100 dilution of this antibody detected dystrophin in human skeletal muscle tissue sections.
Immunofluorescence Analysis: A 1:100 dilution of this antibody detected dystrophin in human skeletal muscle tissue sections.
Application
The unconjugated antibody (Cat. No. MABT827) and Alexa Fluor™ 488 conjugate (Cat. No. MABT827-AF488) are also available for Immunohistochemistry, Immunofluorescence, and Western Blotting applications.
This mouse monoclonal Anti-Dystrophin Antibody, clone 2C6 (MANDYS106), Alexa Fluor™ 555 Conjugate, Cat. No. MABT827-AF555 is validated for use in Immunofluorescence for the detection of Dystrophin.
General description
Dystrophin (UniProt P11532) is encoded by the DMD (also known as BMD, CMD3B, DXS142, DXS164, DXS206, DXS230, DXS239, DXS268, DXS269, DXS270, DXS272, MRX85) gene (Gene ID 1756) in human. Dystrophin is localized to the inner part of the muscle fiber cell membrane (sarcolemma), where it forms the dystrophin-associated glycoprotein complex (DGC) that links the extracellular matrix to the actin cytoskeleton. Dystrophin plays an important role in stabilizing the muscle fibre against the mechanical forces of muscle contraction by providing a shock-absorbing connection between the cytoskeleton and the extracellular matrix. Duchenne muscular dystrophy (DMD) is caused by gene mutations that disrupt the open reading frame (ORF) and prevent the full translation of dystrophin. ORF restoration by exon skipping using antisense oligonucleotides targeted to splicing elements are designed to transform the DMD phenotype to that of the milder disorder, Becker muscular dystrophy (BMD), typically caused by in-frame dystrophin deletions that allow the production of an internally deleted but partially functional dystrophin.
~427 kDa observed.
Other Notes
Concentration: Please refer to lot specific datasheet.
Physical form
Purified mouse IgG2a Alexa Fluor™ 555 conjugate in buffer containing PBS, 1.5% BSA with 0.05% sodium azide
Legal Information
ALEXA FLUOR is a trademark of Life Technologies
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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