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Merck
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MCKP1-110K

MILLIPLEX® Mouse Immuno-Oncology Checkpoint Protein Panel 1

Configurable Mouse Immuno-Oncology Checkpoint Protein 28-Plex Panel 1

别名:

Luminex mouse immuno oncology panel, checkpoint inhibitor multiplex assay, mouse IO panel, mouse cancer immunotherapy assay, mouse immune checkpoint profiling kit

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NACRES:
NA.47
UNSPSC Code:
12161503

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species reactivity

mouse

Quality Level

200

packaging

pkg of 1 ea

manufacturer/tradename

Milliplex®

assay range

accuracy: 101
(Galectin-1), accuracy: 103
(CD80/B7-1), accuracy: 103
(IFNγ), accuracy: 104
(CTLA-4/CD152), accuracy: 104
(PD-L2), accuracy: 104
(TLR-2), accuracy: 105
(4-1BBL/TNFSF9), accuracy: 105
(BCA-1/CXCL-13), accuracy: 105
(CD25/IL-2Rα), accuracy: 105
(IL-10), accuracy: 105
(LAG-3), accuracy: 106
(5’-NT/CD73), accuracy: 106
(PD-1), accuracy: 106
(TIM-3), accuracy: 106
(TNFα), accuracy: 107
(CD137/4-1BB), accuracy: 107
(CD27), accuracy: 108
(E-Cadherin), accuracy: 108
(Galectin-3), accuracy: 108
(HVEM), accuracy: 109
(CD40), accuracy: 109
(GITR), accuracy: 110
(B7-H2/ICOSL), accuracy: 110
(CD226/DNAM-1), accuracy: 111
(BTLA), accuracy: 94
(GranzymeB), accuracy: 95
(B7-H3/CD276), accuracy: 96
(PD-L1), standard curve range: 1.4 - 1000 pg/mL
(HVEM), standard curve range: 11 - 8000 pg/mL
(IL-10), standard curve range: 137-100,000 pg/mL
(5’-NT/CD73), standard curve range: 14 - 10000 pg/mL
(CD226/DNAM-1), standard curve range: 14 - 10000 pg/mL
(CD40), standard curve range: 14 - 10000 pg/mL
(PD-L1), standard curve range: 2.1 - 1500 pg/mL
(IFNγ), standard curve range: 2.7 - 2000 pg/mL
(CD25/IL-2Rα), standard curve range: 21-15000 pg/mL
(BTLA), standard curve range: 27-20000 pg/mL
(B7-H2/ICOSL), standard curve range: 27-20000 pg/mL
(BCA-1/CXCL-13), standard curve range: 3.4 - 2500 ng/mL
(Galectin-1), standard curve range: 3.4-2500 ng/mL
(B7-H3/CD276), standard curve range: 34.3 - 25000 pg/mL
(CD80/B7-1), standard curve range: 342 - 250000 pg/mL
(E-Cadherin), standard curve range: 4.1 - 3000 pg/mL
(TNFα), standard curve range: 41 - 30000 pg/mL
(GITR), standard curve range: 41 - 30000 pg/mL
(Galectin-3), standard curve range: 412 - 300000 pg/mL
(LAG-3), standard curve range: 412 - 300000 pg/mL
(TLR-2), standard curve range: 5.5 - 4000 pg/mL
(CD137/4-1BB), standard curve range: 5.5 - 4000 pg/mL
(CTLA-4/CD152), standard curve range: 5.5 - 4000 pg/mL
(TIM-3), standard curve range: 55 - 40000 pg/mL
(CD27), standard curve range: 55 - 40000 pg/mL
(PD-1), standard curve range: 6.9 - 5000 pg/mL
(PD-L2), standard curve range: 8.2 - 6000 pg/mL
(GranzymeB)

technique(s)

multiplexing: suitable

input

cell lysate
cell culture supernatant

detection method

fluorometric (Luminex® xMAP® technology)

shipped in

wet ice

storage temp.

2-8°C

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General description

Immune checkpoint proteins are key regulators of the immune system and drug targets of cancer immunotherapy. Immune checkpoint molecules have been found on the cell surface of immune cells and tumor cells as activating receptors or inhibitory receptors. Immune checkpoint inhibitors, such as blocking antibodies to cytotoxic T lymphocyte-associated antigen-4 (CTLA-4), programmed cell death protein-1 (PD-1) and programmed cell death ligand 1 (PD-L1), have demonstrated significant efficacy in the treatment of a variety of cancers. Recent studies have also shown many immune checkpoint proteins can undergo alternative splicing or proteolytic cleavage to produce soluble checkpoint proteins. The expression levels of soluble and cell-surface immune checkpoint proteins in the circulation and in tumor-microenvironment (TME) may be used as putative immune-based biomarkers for cancer research and biomarker discovery in immunological diseases.

Application

MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 28 analytes in mouse serum, plasma, cell culture supernatant, cell lysate, and tissue/tumor extract samples.

Analytes included: 4-1BBL/TNFSF9, 5′-NT/CD73, B7-H2/ICOSL, B7-H3/CD276, BCA-1/CXCL-13, BTLA, CD137/4-1BB, CD226/DNAM-1, CD25/IL-2Rα, CD27, CD40, CD80/B7-1, CTLA-4/CD152, E-cadherin, Galectin-1, Galectin-3, GITR, Granzyme B, HVEM, IFNγ, IL-10, LAG-3, PD-1, PD-L1, PD-L2, TIM-3, TLR-2, and TNFα

Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.

Features and Benefits

Wide Analyte Coverage: Includes both co-stimulatory and co-inhibitory checkpoint molecules, such as PD-1, PD-L1, PD-L2, CTLA-4, TIM-3, LAG-3, CD80, CD40, CD137, GITR, and more.

Accelerates Immuno-Oncology Research: Enables detailed profiling of immune checkpoint dynamics in tumor microenvironments and circulation and supports studies on immune escape mechanisms and response to immunotherapies.

Supports Biomarker Discovery: Facilitates identification of soluble checkpoint proteins as potential biomarkers for cancer and immunological diseases.

Verified Performance: Offers lot-to-lot consistency and analytical validation, critical for reproducible results in research.

Flexible Applications: Suitable for basic research, preclinical studies, and drug development involving mouse models.

Legal Information

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Disclaimer

For research use only. Not for use in diagnostic procedures.

Label License/Sticker for Assay Product:

By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2

target_organs

Respiratory Tract

存储类别

10 - Combustible liquids

wgk

WGK 3

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