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Merck
CN

MT17MAG47PMX25BK

MILLIPLEX® Mouse TH17 Panel

Bulk (Space Saver) Premixed Mouse Th17 25-Plex Panel

别名:

Mouse TH17 Panel, TH17 Magnetic Bead Panel, murine Th17 assay

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UNSPSC Code:
12161503
NACRES:
NA.47
eCl@ss:
32161000

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产品名称

MILLIPLEX® Mouse TH17 Panel, Bulk (Space Saver) Premixed Mouse Th17 25-Plex Panel

species reactivity

human

manufacturer/tradename

Milliplex®

Quality Level

200

packaging

1 ea of

assay range

linearity: 111.0%
(1:04)
linearity: 113.1%
(1:08)
standard curve range: 1.5-1,500 pg/mL
(IL-4)
standard curve range: 10-10,000 pg/mL
(IL-17F)
standard curve range: 127-130,000 pg/mL
(IL-28B)
standard curve range: 15-15,000 pg/mL
(IL-1β)
standard curve range: 2.4-2,500 pg/mL
(IL-22)
standard curve range: 20-20,000 pg/mL
(IL-10, IL-12(p70), & IL-21)
standard curve range: 3.4-3,500 pg/mL
(TNFα)
standard curve range: 34-35,000 pg/mL
(GM-CSF & IL-15)
standard curve range: 342-350,000 pg/mL
(IL-23)
standard curve range: 39-40,000 pg/mL
(IL-13 & IL-17A)
standard curve range: 4.9-5,000 pg/mL
(IL-5)
standard curve range: 488-500,000 pg/mL
(TNFβ)
standard curve range: 49-50,000 pg/mL
(CD40L IL-31 & MIP-3α)
standard curve range: 586-600,000 pg/mL
(IL-17E/ IL-25)
standard curve range: 6.9-6,000 pg/mL
(IL-2)
standard curve range: 7.8-8,000 pg/mL
(IFNγ & IL-6)
standard curve range: 78-80,000 pg/mL
(IL-33)
standard curve range: 879-900,000 pg/mL
(IL-27)

technique(s)

multiplexing: suitable

input

cell culture supernatant(s)

detection method

fluorometric (Luminex® xMAP® technology)

shipped in

wet ice

storage temp.

2-8°C

相关类别

Legal Information

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Disclaimer

For research use only. Not for use in diagnostic procedures.

Label License/Sticker for Assay Product:

By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

Features and Benefits

Th17 Pathway Insights in One Assay: Unlock a complete view of Th17-related immune activity with simultaneous measurement of key cytokines—perfect for uncovering disease mechanisms. Efficient Use of Precious Samples: Requires only a small volume, preserving valuable mouse specimens while delivering robust data. Boost Productivity with Multiplex Power: Analyze multiple biomarkers at once using Luminex® magnetic bead technology—saving time, reducing costs, and increasing throughput. Built for Mouse Research: Specifically formulated for mouse-based studies, ensuring compatibility and consistent results across sample types. Advance Autoimmune and Cancer Research: Ideal for exploring Th17 involvement in chronic inflammation, immune dysregulation, and tumor progression.

General description

Th17 cells, a subset of CD4+ T helper cells, play a crucial role in immune responses by producing a range of cytokines, particularly interleukin-17 (IL-17). In mice, Th17 cytokines, including IL-17A, IL-17F, and IL-22, are involved in promoting inflammation and are key players in the defense against extracellular pathogens, as well as in the pathogenesis of autoimmune diseases. These cytokines help to recruit neutrophils and enhance the production of antimicrobial peptides, contributing to the host′s immune response.

Application

MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze 25 analytes in mouse serum, plasma, and cell culture supernatants.

Analytes included: CD40 Ligand, GM-CSF, IFN-γ, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12 (p70), IL-13, IL-15, IL-17A, IL-17E/IL-25, IL-17F, IL-21, IL-22, IL-23, IL-27, IL-28B, IL-31, IL-33, MIP-3α/CCL20, TNF-α, TNFβ

Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2

target_organs

Respiratory Tract

存储类别

10 - Combustible liquids

wgk

WGK 3

法规信息

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Yu-Wen Liu et al.
JCI insight, 7(11) (2022-05-04)
Positive regulatory domain 1 (PRDM1) encodes B lymphocyte-induced maturation protein 1 (BLIMP1), also known as a master regulator of T cell homeostasis. We observed a negative relationship between Blimp-1 and IL-21 based on our previous data that Blimp-1 overexpression in

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