MTH17MAG-47K

MILLIPLEX^®小鼠TH17磁珠组套 - 免疫学多重检测试剂盒

Name: MILLIPLEX<SUP>®</SUP>小鼠TH17磁珠组套 - 免疫学多重检测试剂盒
Brand: MM

Configurable Mouse Th17 25-Plex Panel

别名:

Millipore Mouse Immunology Panel, Mouse Immunology Protein Multiplex Assay, murine Th17 assay

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关于此项目

UNSPSC Code:

12161503

NACRES:

NA.84

eCl@ss:

32161000

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产品名称

MILLIPLEX^®小鼠TH17磁珠组套 - 免疫学多重检测试剂盒, Configurable Mouse Th17 25-Plex Panel

species reactivity

mouse

manufacturer/tradename

Milliplex^®

Quality Level

200

packaging

1 ea of

assay range

linearity: 111.0%
(1:04)
linearity: 113.1%
(1:08)
standard curve range: 1.5-1,500 pg/mL
(IL-4)
standard curve range: 10-10,000 pg/mL
(IL-17F)
standard curve range: 127-130,000 pg/mL
(IL-28B)
standard curve range: 15-15,000 pg/mL
(IL-1β)
standard curve range: 2.4-2,500 pg/mL
(IL-22)
standard curve range: 20-20,000 pg/mL
(IL-10, IL-12(p70), & IL-21)
standard curve range: 3.4-3,500 pg/mL
(TNFα)
standard curve range: 34-35,000 pg/mL
(GM-CSF & IL-15)
standard curve range: 342-350,000 pg/mL
(IL-23)
standard curve range: 39-40,000 pg/mL
(IL-13 & IL-17A)
standard curve range: 4.9-5,000 pg/mL
(IL-5)
standard curve range: 488-500,000 pg/mL
(TNFβ)
standard curve range: 49-50,000 pg/mL
(CD40L IL-31 & MIP-3α)
standard curve range: 586-600,000 pg/mL
(IL-17E/ IL-25)
standard curve range: 6.9-6,000 pg/mL
(IL-2)
standard curve range: 7.8-8,000 pg/mL
(IFNγ & IL-6)
standard curve range: 78-80,000 pg/mL
(IL-33)
standard curve range: 879-900,000 pg/mL
(IL-27)

technique(s)

multiplexing: suitable

input

cell culture supernatant(s)

detection method

fluorometric (Luminex^® xMAP^® technology)

shipped in

wet ice

storage temp.

2-8°C

Legal Information

Luminex is a registered trademark of Luminex Corp

MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany

xMAP is a registered trademark of Luminex Corp

Application

MILLIPLEX^® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 25 analytes in mouse serum, plasma, and cell culture supernatants.

Analytes included: CD40 Ligand, GM-CSF, IFN-γ, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12 (p70), IL-13, IL-15, IL-17A, IL-17E/IL-25, IL-17F, IL-21, IL-22, IL-23, IL-27, IL-28B, IL-31, IL-33, MIP-3α/CCL20, TNF-α, TNFβ

Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.

Disclaimer

For research use only. Not for use in diagnostic procedures.

Label License/Sticker for Assay Product:

By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

Features and Benefits

Comprehensive Th17 Profiling: Simultaneously measures a wide range of Th17-related cytokines and chemokines, including IL-17A, IL-17F, IL-21, IL-22, IL-23, and more—ideal for studying autoimmune and inflammatory pathways.

Minimal Sample Volume Required: Optimized for small sample inputs, making it perfect for mouse models and limited biological material.

Multiplex Efficiency with Luminex^® xMAP^® Technology: Magnetic bead-based format allows simultaneous detection of multiple analytes in a single well, saving time, reagents, and sample volume.

Validated for Mouse Samples: Designed specifically for mouse serum, plasma, and cell culture supernatants, ensuring compatibility and performance in preclinical studies.

Ideal for Autoimmune and Cancer Research: Supports investigation into Th17 cell roles in diseases such as rheumatoid arthritis, Crohn’s disease, diabetes, and cancer progression.

General description

Th17 cells, a subset of CD4+ T helper cells, play a crucial role in immune responses by producing a range of cytokines, particularly interleukin-17 (IL-17). In mice, Th17 cytokines, including IL-17A, IL-17F, and IL-22, are involved in promoting inflammation and are key players in the defense against extracellular pathogens, as well as in the pathogenesis of autoimmune diseases. These cytokines help to recruit neutrophils and enhance the production of antimicrobial peptides, contributing to the host′s immune response.

pictograms

GHS08,GHS05,GHS07,GHS09

signalword

Danger

pcodes

P273 - P280 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338 - P314

target_organs

Respiratory Tract

存储类别

10 - Combustible liquids

wgk

WGK 3

hcodes

H302 + H312 + H332,H315,H317,H318,H373,H411

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2

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In vitro spleen cell cytokine responses of adult mice immunized with a recombinant PorA (major outer membrane protein [MOMP]) from Campylobacter jejuni.

M John Albert et al.

Scientific reports, 9(1), 12024-12024 (2019-08-21)

There is no information on cytokine profiles for use as markers of protection in Campylobacter jejuni infection. To study this, we used outer membrane protein (MOMP [PorA]) as the vaccine for protection and spleen cell cytokines as markers of protection.

C5a Blockade Increases Regulatory T Cell Numbers and Protects Against Microvascular Loss and Epithelial Damage in Mouse Airway Allografts.

Mohammad Afzal Khan et al.

Frontiers in immunology, 9, 1010-1010 (2018-06-09)

Microvascular injury during acute rejection has been associated with massive infiltration of CD4+ T effector cells, and the formation of complement products (C3a and C5a). Regulatory T cells (Tregs) are potent immunosuppressors of the adaptive immune system and have proven

IL-10 Mediated Immunomodulation Limits Subepithelial Fibrosis and Repairs Airway Epithelium in Rejecting Airway Allografts.

Mohammad Afzal Khan et al.

Cells, 10(5) (2021-06-03)

Interleukin-10 plays a vital role in maintaining peripheral immunotolerance and favors a regulatory immune milieu through the suppression of T effector cells. Inflammation-induced microvascular loss has been associated with airway epithelial injury, which is a key pathological source of graft

STAT4 Directs a Protective Innate Lymphoid Cell Response to Gastrointestinal Infection.

Sarah J Dulson et al.

Journal of immunology (Baltimore, Md. : 1950), 203(9), 2472-2484 (2019-09-29)

Innate lymphoid cells (ILCs) are strategically positioned at mucosal barrier surfaces where they respond quickly to infection or injury. Therefore, we hypothesized that ILCs are key contributors to the early immune response in the intestine against Listeria monocytogenes Using a

Hedgehog Signaling as a Therapeutic Target for Airway Remodeling and Inflammation in Allergic Asthma.

Anthony Tam et al.

Cells, 11(19) (2022-10-15)

Genome-wide association studies (GWAS) have shown that variants of patched homolog 1 (PTCH1) are associated with lung function abnormalities in the general population. It has also been shown that sonic hedgehog (SHH), an important ligand for PTCH1, is upregulated in

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MILLIPLEX^®小鼠TH17磁珠组套 - 免疫学多重检测试剂盒