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Merck
CN

MX1390

NMP

OmniSolv®

别名:

1-Methyl-2-Pyrrolidone, N-Methyl-2-Pyrrolidinone,NMP, Methyl Pyrrolidone

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线性分子式:
(CH3)-NC(=O)CH2CH2CH2-
化学文摘社编号:
872-50-4
UNSPSC Code:
12352115
EC Index Number:
212-828-1
MDL number:
MFCD00003193
Assay:
≥99.7% (GC)
Technique(s):
HPLC: suitable
LC/MS: suitable
gas chromatography (GC): suitable
Bp:
202 °C/1013 hPa
Vapor pressure:
0.32 hPa ( 20 °C)

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产品名称

1-Methyl-2-pyrrolidone, OmniSolv®

SMILES string

N1(CCCC1=O)C

InChI

1S/C5H9NO/c1-6-4-2-3-5(6)7/h2-4H2,1H3

InChI key

SECXISVLQFMRJM-UHFFFAOYSA-N

vapor pressure

0.32 hPa ( 20 °C)

product line

OmniSolv®

assay

≥99.7% (GC)

form

liquid

technique(s)

HPLC: suitable
LC/MS: suitable
gas chromatography (GC): suitable

impurities

≤0.08% Water (H2O)
≤1 μeq/g Titrable base

ign. residue

≤5 ppm

color

APHA: ≤10

pH

8.5-10.0 (20 °C, 100 g/L in H2O)

bp

202 °C/1013 hPa

mp

-24 °C

transition temp

flash point 91 °C

solubility

1000 g/L

density

1.03 g/cm3 at 20 °C

UV cutoff

≤270 nm

UV absorption

λ: 270 nm Amax: ≤1.00
λ: 300 nm Amax: ≤0.20
λ: 325 nm Amax: ≤0.10
λ: 350 nm Amax: ≤0.03
λ: 400 nm Amax: ≤0.005

shipped in

ambient

storage temp.

room temp

Quality Level

100

相关类别

Analysis Note

Assay (GC)99.7% minColor (APHA)10 maxFiltered through 0.2 µm filterTo pass testFormClear liquidInfrared SpectrumConforms to standardResidue after ignition5ppm maxTitrable base1µeq/g maxUV Abs. at 270 nm1.00AU maxUV Abs. at 300 nm0.20AU maxUV Abs. at 325 nm0.10AU maxUV Abs. at 350 nm0.03AU maxUV Abs. at 400 nm0.005AU maxUV Cut-off270nm maxWater (H2O)0.08% max

Application

NMP may be used as a solvent
  • in a modified Fmoc-deprotection during solid-phase peptide synthesis for the reduction of diketopiperazine formation.
  • in gel permeation chromatography (GPC) or size-exclusion chromatography (SEC) for analyzing high-molecular-weight polymers
OmniSolv®

General description

NMP, also known as N-Methyl-2-pyrrolidone, is a versatile, water-miscible solvent widely recognized for its ability to improve the solubility and permeability of a broad range of pharmaceutical compounds. Its high thermal stability with a boiling point of 202 °C is well-suited for formulations that require heat sterilization. These properties make it a reliable and effective solubilizing agent for pharmaceutical development.

Packaging

M-Bottle for Solvents
As a global leader in lab reagents, we are constantly looking for new ways to optimize the safety of our products. The newly developed 4L solvent bottle design features advanced sealing technology that eliminates leaks to make the handling of solvents safer and more convenient than ever before.
See all the new features here!
is packaged in 4L amber glass bottle

Preparation Note

Product filtered through a 0.2 μm filter

Legal Information

OMNISOLV is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

flash_point_f

195.8 °F - Pensky-Martens closed cup

flash_point_c

91 °C - Pensky-Martens closed cup

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