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Merck
CN

MX1390

Supelco

NMP

OmniSolv®

别名:

1-Methyl-2-Pyrrolidone, N-Methyl-2-Pyrrolidinone,NMP, Methyl Pyrrolidone

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关于此项目

线性分子式:
(CH3)-NC(=O)CH2CH2CH2-
CAS Number:
872-50-4
MDL编号:
MFCD00003193
UNSPSC代码:
12352115
EC索引号:
212-828-1

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Product Name

1-Methyl-2-pyrrolidone, OmniSolv®

蒸汽压

0.32 hPa ( 20 °C)

质量水平

100

产品线

OmniSolv®

方案

≥99.7% (GC)

表单

liquid

技术

HPLC: suitable
LC/MS: suitable
gas chromatography (GC): suitable

杂质

≤0.08% Water (H2O)
≤1 μeq/g Titrable base

灼烧残渣

≤5 ppm

颜色

APHA: ≤10

pH值（酸碱度）

8.5-10.0 (20 °C, 100 g/L in H2O)

沸点

202 °C/1013 hPa

mp

-24 °C

转变温度

flash point 91 °C

溶解性

1000 g/L

密度

1.03 g/cm3 at 20 °C

UV cutoff

≤270 nm

紫外吸收

λ: 270 nm Amax: ≤1.00
λ: 300 nm Amax: ≤0.20
λ: 325 nm Amax: ≤0.10
λ: 350 nm Amax: ≤0.03
λ: 400 nm Amax: ≤0.005

运输

ambient

储存温度

room temp

SMILES字符串

N1(CCCC1=O)C

InChI

1S/C5H9NO/c1-6-4-2-3-5(6)7/h2-4H2,1H3

InChI key

SECXISVLQFMRJM-UHFFFAOYSA-N

相关类别

一般描述

NMP, also known as N-Methyl-2-pyrrolidone, is a versatile, water-miscible solvent widely recognized for its ability to improve the solubility and permeability of a broad range of pharmaceutical compounds. Its high thermal stability with a boiling point of 202 °C is well-suited for formulations that require heat sterilization. These properties make it a reliable and effective solubilizing agent for pharmaceutical development.

应用

NMP may be used as a solvent
  • in a modified Fmoc-deprotection during solid-phase peptide synthesis for the reduction of diketopiperazine formation.
  • in gel permeation chromatography (GPC) or size-exclusion chromatography (SEC) for analyzing high-molecular-weight polymers
OmniSolv®

包装

M-Bottle for Solvents
As a global leader in lab reagents, we are constantly looking for new ways to optimize the safety of our products. The newly developed 4L solvent bottle design features advanced sealing technology that eliminates leaks to make the handling of solvents safer and more convenient than ever before.
See all the new features here!
is packaged in 4L amber glass bottle

制备说明

Product filtered through a 0.2 μm filter

分析说明

Assay (GC)99.7% minColor (APHA)10 maxFiltered through 0.2 µm filterTo pass testFormClear liquidInfrared SpectrumConforms to standardResidue after ignition5ppm maxTitrable base1µeq/g maxUV Abs. at 270 nm1.00AU maxUV Abs. at 300 nm0.20AU maxUV Abs. at 325 nm0.10AU maxUV Abs. at 350 nm0.03AU maxUV Abs. at 400 nm0.005AU maxUV Cut-off270nm maxWater (H2O)0.08% max

法律信息

OMNISOLV is a registered trademark of Merck KGaA, Darmstadt, Germany

象形图

Health hazardExclamation mark
GHS08,GHS07

警示用语：

Danger

危险分类

Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 1

闪点(°F)

195.8 °F - Pensky-Martens closed cup

闪点(°C)

91 °C - Pensky-Martens closed cup

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