产品名称
Anti-IKKβ Mouse mAb (10AG2), liquid, clone 10AG2, Calbiochem®
biological source
mouse
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
10AG2, monoclonal
form
liquid
contains
≤0.1% sodium azide as preservative
species reactivity
human
manufacturer/tradename
Calbiochem®
storage condition
do not freeze
isotype
IgG1
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... IKBKB(3551)
General description
Recognizes the ~87 kDa IKKβ protein in Daudi cells.
This Anti-IKKβ Mouse mAb (10AG2) is validated for use in Immunoblotting for the detection of IKKβ.
Immunoaffinity purified mouse monoclonal antibody. Recognizes the ~87 kDa IKKβ protein.
Other Notes
Antibody should be titrated for optimal results in individual systems.
Delhase, M., et al. 1999. Science284, 309.
Li. Q., et al. 1999. Science284, 321.
Didonato, et al. 1997. Nature388, 548.
Lee, F.S., et al. 1997. Cell88, 213.
Malinin, N.L., et al. 1997. Nature385, 540.
Mercurio, F., et al. 1997. Science278, 860.
Regnier, C.H., et al. 1997. Cell90, 373.
Verma, I. And Stevenson, J.K. 1997. Proc. Nat. Acad. Sci. USA94, 11758.
Verma, I.M., et al. 1995. Genes. Dev.9, 2723.
Li. Q., et al. 1999. Science284, 321.
Didonato, et al. 1997. Nature388, 548.
Lee, F.S., et al. 1997. Cell88, 213.
Malinin, N.L., et al. 1997. Nature385, 540.
Mercurio, F., et al. 1997. Science278, 860.
Regnier, C.H., et al. 1997. Cell90, 373.
Verma, I. And Stevenson, J.K. 1997. Proc. Nat. Acad. Sci. USA94, 11758.
Verma, I.M., et al. 1995. Genes. Dev.9, 2723.
Immunogen
Human
a recombinant protein consisting of full-length human IKKβ fused to a His•Tag sequence
Disclaimer
Toxicity: Standard Handling (A)
Analysis Note
Positive Control
Daudi cells
Daudi cells
Application
Immunoblotting (1-4 g/ml, chemiluminescence)
Packaging
Please refer to vial label for lot-specific concentration.
Physical form
In PBS, 0.2% gelatin, pH 7.4.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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Jonathan M Starkey et al.
Diabetes, 55(5), 1252-1259 (2006-04-29)
Evidence of diabetes-induced nuclear factor-kappaB (NF-kappaB) activation has been provided with DNA binding assays or nuclear localization with immunohistochemistry, but few studies have explored mechanisms involved. We examined effects of diabetes on proteins comprising NF-kappaB canonical and noncanonical activation pathways
Tamara P Martin et al.
Cellular signalling, 51, 166-175 (2018-07-31)
Calcium/calmodulin dependent protein kinase IIδ (CaMKIIδ) acts as a molecular switch regulating cardiovascular Ca2+ handling and contractility in health and disease. Activation of CaMKIIδ is also known to regulate cardiovascular inflammation and is reported to be required for pro-inflammatory NF-κB
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