OP14
Anti-c-ErbB2/c-Neu (Ab-2) Mouse mAb (9G6)
liquid, clone 9G6, Calbiochem®
别名:
Anti-ErbB2, Anti-Erythroblastosis Virus, Anti-HER2, Anti-c-Neu
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Clone:
9G6, monoclonal
Species reactivity:
human
Application:
—
Citations:
1
biological source
mouse
antibody form
purified antibody
antibody product type
primary antibodies
clone
9G6, monoclonal
form
liquid
contains
≤0.1% sodium azide as preservative
species reactivity
human
manufacturer/tradename
Calbiochem®
storage condition
do not freeze
dilution
(Frozen Sections (5 µg/mL)
Immunoprecipitation (1 µg/sample)
Paraffin Sections )
isotype
IgG1
shipped in
wet ice
Quality Level
Gene Information
human ... ERBB2(2064)
target post-translational modification
unmodified
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General description
Anti-c-ErbB2/c-Neu (Ab-2), mouse monoclonal, clone 9G6, recognizes the ~185 kDa c-ErbB2/c-Neu SK-BR-3 cells and breast carcinoma. It is validated for IP and IHC on frozen and paraffin sections.
Recognizes the ~185 kDa c-ErbB2/c-Neu protein in SK-BR-3 cells and breast carcinoma tissue. Does not cross-react with v-ErbB2 or the EGF receptor.
This clone expresses the kappa light chain isotype. Purified mouse monoclonal antibody generated by immunizing BALB/c mice with the specified immunogen and fusing splenocytes with SP2/0 Ag14 myeloma cells. Recognizes the ~185 kDa c-ErbB2/c-neu protein.
Application
Frozen Sections (5 µg/mL)Immunoprecipitation (1 µg/sample)Paraffin Sections
Packaging
Please refer to vial label for lot-specific concentration.
Analysis Note
Negative Control
Normal skin tissue or HepG2 cells
Normal skin tissue or HepG2 cells
Other Notes
Immunoprecipitates the 185 kDa c-neu protein and has been reported to stain formalin-fixed paraffin-embedded tissue sections of human breast carcinomas overexpressing the c-neu protein (see application references). This antibody reacts with a cell surface epitope of c-neu but does not cross-react with the EGF receptor. In one study ductal carcinomas in situ displaying large-cell, comedo growth type, were stained while none of 16 ductal carcinomas in situ of small-cell, papillary, or cribiform growth type were stained by this antibody. Antibody should be titrated for optimal results in individual systems.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
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存储类别
10 - Combustible liquids
wgk
nwg
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Prajakta S Oak et al.
International journal of cancer, 131(12), 2808-2819 (2012-04-19)
A major obstacle in the successful treatment of cancer is the occurrence of chemoresistance. Cancer cells surviving chemotherapy and giving rise to a recurrence of the tumor are termed cancer stem cells and can be identified by elevated levels of
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