OP39
Anti-c-ErbB2/c-Neu (Ab-5) Mouse mAb (TA-1)
liquid, clone TA-1, Calbiochem®
别名:
Anti-HER2, Anti-c-Neu, Anti-ErbB2, Anti-Erythroblastosis Virus
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关于此项目
NACRES:
NA.43
UNSPSC Code:
12352203
Clone:
TA-1, monoclonal
Species reactivity:
human
Application:
Citations:
3
产品名称
Anti-c-ErbB2/c-Neu (Ab-5) Mouse mAb (TA-1), liquid, clone TA-1, Calbiochem®
biological source
mouse
antibody form
purified antibody
antibody product type
primary antibodies
clone
TA-1, monoclonal
form
liquid
contains
≤0.1% sodium azide as preservative
species reactivity
human
should not react with
mouse, rat
manufacturer/tradename
Calbiochem®
storage condition
do not freeze
dilution
(Flow Cytometry (5 µg/mL,
Frozen Sections (5 µg/mL)
Immunoblotting
Immunofluorescence (5 µg/mL,
Immunoprecipitation (1 µg/sample,
Neutralization Studies (not recommended and application references))
isotype
IgG1
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ERBB2(2064)
Analysis Note
Positive Control
SK-BR-3 cells
SK-BR-3 cells
Application
Flow Cytometry (5 µg/ml, see application references)
Frozen Sections (5 µg/ml)
Immunoblotting (see application references)
Immunofluorescence (5 µg/ml, see application references)
Immunoprecipitation (1 µg/sample, see application references)
Neutralization Studies (not recommended, see comments and application references)
Frozen Sections (5 µg/ml)
Immunoblotting (see application references)
Immunofluorescence (5 µg/ml, see application references)
Immunoprecipitation (1 µg/sample, see application references)
Neutralization Studies (not recommended, see comments and application references)
Disclaimer
Toxicity: Standard Handling (A)
General description
Anti-c-ErbB2/c-Neu (Ab-5), mouse monoclonal, clone TA-, recognizes the ~185 kDa c-ErbB2/c-Neu protein in SK-BR-3 cells. It is validated for FC, WB, IF, IP, and IHC on frozen sections.
Purified mouse monoclonal antibody generated by immunizing BALB/c mice with the specified immunogen and fusing spleonocytes with SP2/0 mouse myeloma cells (see application references). Recognizes the c-ErbB2/c-neu protein.
Recognizes the ~185 kDa c-ErbB2/c-Neu protein in SK-BR-3 cells.
Other Notes
DiFiore, P.P., et al. 1987. Science237, 178.
Slamon, D.J., et al. 1987. Science235, 177.
Varley, J.M., et al. 1987. Oncogene1, 423.
Yamamoto, T., et al. 1986. Nature319, 230.
Blick, M., et al. 1984. Blood64, 1234.
Schwab, M., et al. 1984 Cold Spring Harbor Laboratory2, 215.
Bargmann, C.I., et al. 1968. Nature319, 226.
Slamon, D.J., et al. 1987. Science235, 177.
Varley, J.M., et al. 1987. Oncogene1, 423.
Yamamoto, T., et al. 1986. Nature319, 230.
Blick, M., et al. 1984. Blood64, 1234.
Schwab, M., et al. 1984 Cold Spring Harbor Laboratory2, 215.
Bargmann, C.I., et al. 1968. Nature319, 226.
Recognizes an extracellular epitope and does not cross react with human EGF-receptor. It will not inhibit in vivo protein tyrosine kinase activity. Antibody should be titrated for optimal results in individual systems.
Packaging
Please refer to vial label for lot-specific concentration.
Physical form
In 50 mM PBS, 0.2% gelatin, pH 7.5.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Vineesh Indira Chandran et al.
Molecular cancer research : MCR, 18(4), 644-656 (2020-01-05)
The antibody-drug conjugate trastuzumab-emtansine (T-DM1) offers an additional treatment option for patients with HER2-amplified tumors. However, primary and acquired resistance is a limiting factor in a significant subset of patients. Hypoxia, a hallmark of cancer, regulates the trafficking of several
Heather Gibson et al.
Oncoimmunology, 4(1), e984523-e984523 (2015-05-08)
The goal is to elucidate the immune modulating activity of an adenovirus (Adv) vector which showed therapeutic activity in human clinical trials. The oncolytic adenovirus (Adv/CD-TK) expressing two suicide genes was tested in two HER2/neu positive BALB/c mouse mammary tumor
Min Gyu Jeong et al.
Experimental & molecular medicine, 53(2), 291-299 (2021-02-20)
Various repertoires of membrane protein interactions determine cellular responses to diverse environments around cells dynamically in space and time. Current assays, however, have limitations in unraveling these interactions in the physiological states in a living cell due to the lack
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