PC57
Anti-MSH2 (Ab-3) Rabbit pAb
liquid, Calbiochem®
别名:
Anti-Mismatch Repair Protein 2
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关于此项目
UNSPSC Code:
12352203
Clone:
polyclonal
Species reactivity:
human, mouse
Application:
—
Citations:
4
biological source
rabbit
antibody form
purified antibody
antibody product type
primary antibodies
clone
polyclonal
form
liquid
does not contain
preservative
species reactivity
human, mouse
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, avoid repeated freeze/thaw cycles
isotype
IgG
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... MSH2(4436)
General description
Purified rabbit polyclonal antibody. Recognizes the ~100 kDa MSH2 protein.
Recognizes the ~100 kDa MSH2 protein in HCT116 and SW480 cells and in colon tissue.
This Anti-MSH2 (Ab-3) Rabbit pAb is validated for use in Frozen Sections, Immunoblotting, Immunoprecipitation, Paraffin Sections for the detection of MSH2 (Ab-3).
Immunogen
full length, recombinant, human MSH2
Application
Frozen Sections (2 µg/ml)
Immunoblotting (1 µg/ml, chemiluminescence)
Immunoprecipitation (1 µg/sample)
Paraffin Sections (see application references)
Immunoblotting (1 µg/ml, chemiluminescence)
Immunoprecipitation (1 µg/sample)
Paraffin Sections (see application references)
Packaging
Please refer to vial label for lot-specific concentration.
Other Notes
Bronner, C.E., et al. 1994. Nature368, 258.
Papadopoulos, N., et al. Science263, 1625.
Peltomäki, P.T. 1994. Ann. Medicine26, 215.
Fishel, R., et al. 1993. Cell75, 1027.
Leach, F.S., et al. 1993. Cell75, 1215.
Lindbolm, A., et al. 1993. Nat. Genet.5, 279.
Papadopoulos, N., et al. Science263, 1625.
Peltomäki, P.T. 1994. Ann. Medicine26, 215.
Fishel, R., et al. 1993. Cell75, 1027.
Leach, F.S., et al. 1993. Cell75, 1215.
Lindbolm, A., et al. 1993. Nat. Genet.5, 279.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
J Barwell et al.
Journal of medical genetics, 44(8), 516-520 (2007-05-08)
Reports of differential mutagen sensitivity conferred by a defect in the mismatch repair (MMR) pathway are inconsistent in their conclusions. Previous studies have investigated cells established from immortalised human colorectal tumour lines or cells from animal models. We examined primary
Jennifer L Cyr et al.
Molecular carcinogenesis, 51(8), 647-658 (2011-08-13)
Lynch syndrome (LS) is caused by germline mutations in DNA mismatch repair (MMR) genes. MMR recognizes and repairs DNA mismatches and small insertion/deletion loops. Carriers of MMR gene variants have a high risk of developing colorectal, endometrial, ovarian, and other
Jennifer A McKinney et al.
Nature communications, 11(1), 236-236 (2020-01-15)
Alternative DNA structure-forming sequences can stimulate mutagenesis and are enriched at mutation hotspots in human cancer genomes, implicating them in disease etiology. However, the mechanisms involved are not well characterized. Here, we discover that Z-DNA is mutagenic in yeast as
Samar Hassen et al.
Journal of experimental & clinical cancer research : CR, 30, 100-100 (2011-10-25)
A broad population-based assay to detect individuals with Lynch Syndrome (LS) before they develop cancer would save lives and healthcare dollars via cancer prevention. LS is caused by a germline mutation in a DNA mismatch repair (MMR) gene, especially protein
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