跳转至内容
Merck
CN

RBN1MAG-31K

MILLIPLEX® Rat Bone Panel 1

Configurable Rat Bone 8-Plex Panel 1

登录 查看组织和合同定价。

关于此项目

UNSPSC Code:
12161503
NACRES:
NA.84
eCl@ss:
32161000

主要文件

查看所有文档
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助

产品名称

MILLIPLEX® Rat Bone Panel 1, Configurable Rat Bone 8-Plex Panel 1

species reactivity

rat

manufacturer/tradename

Milliplex®

Quality Level

200

packaging

1 ea of

assay range

accuracy: 88-105%
sensitivity: 0.8-42.2 pg/mL
standard curve range: 0.4-1,500 pg/mL
(PTH)
standard curve range: 10-40,000 pg/mL
(ACTH and OPG)
standard curve range: 12-50,000 pg/mL
(DKK-1)
standard curve range: 22-90,000 pg/mL
(FGF-23)
standard curve range: 31-125,000 pg/mL
(Insulin)
standard curve range: 5-20,000 pg/mL
(SOST)
standard curve range: 7-30,000 pg/mL
(Leptin)

technique(s)

multiplexing: suitable

detection method

fluorometric (Luminex® xMAP® technology)

shipped in

wet ice

storage temp.

2-8°C

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

Design your multiplex kit by choosing available analytes within this panel.

Application

  • Analytes: ACTH, DKK1, FGF-23, Insulin, Leptin, Osteoprotegerin (OPG), PTH, Sclerostin (SOST)
  • Recommended Sample Type: Rat serum or plasma
  • Recommended Sample Dilution: 25 μL per well of neat serum or plasma
  • Assay Run Time: Overnight (16-18 hours) at 2-8°C is recommended; alternately incubate for 2 hours at room temperature (20-25°C).
  • Research Category: Bone
  • Research Subcategory: Metabolism

Biochem/physiol Actions

Cross Reactivty
The antibody pairs in each panel do not show cross reactivity to the other analytes within the panel

General description

Bone metabolism is the dynamic process of ongoing bone deposition and resorption, controlled by osteoblasts, osteocytes, and osteoclasts. While osteoblasts and osteocytes (osteoblasts surrounded by matrix) are responsible for bone deposition, osteoclasts are responsible for bone resorption. Both are required to maintain bone structure, as well as an adequate supply of calcium. To maintain this metabolic balance, these cells rely on complex signaling pathways involving hormones and cytokines to achieve the appropriate rates of growth and differentiation.

MILLIPLEX® Rat Bone Panel 1 is an 8-plex kit to be used for the simultaneous quantification of any or all of the following in rat serum and plasma samples: ACTH, OPG, Insulin, Leptin, PTH, DKK1, SOST, and FGF23. This kit uses a 96-well format, contains a lyophilized standard cocktail, two internal assay quality controls and can measure up to 38 samples in duplicate.

The Luminex® xMAP® platform uses a magnetic bead immunoassay format for ideal speed and sensitivity to quantitate multiple analytes simultaneously, dramatically improving productivity while conserving valuable sample volume.

Panel Type: Bone

Other Notes

Please contact Technical Service for linearity of dilution.

Legal Information

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

法规信息

新产品
此项目有

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Cidália Pereira et al.
Nutrients, 11(10) (2019-10-03)
Bone mineral density (BMD) and microstructure depend on estrogens and diet. We assessed the impact of natural mineral-rich water ingestion on distal femur of fructose-fed estrogen-deficient female Sprague Dawley rats. Ovariectomized rats drank tap or mineral-rich waters, with or without
Sok Kuan Wong et al.
International journal of environmental research and public health, 16(18) (2019-09-12)
A positive association between metabolic syndrome (MetS) and osteoporosis has been demonstrated in previous animal studies. The mechanisms of MetS in orchestrating the bone remodelling process have traditionally focused on the interactions between mature osteoblasts and osteoclasts, while the role
Philip E Brandish et al.
European journal of pharmacology, 724, 102-111 (2014-01-01)
Glucocorticoids are used widely in the treatment of inflammatory diseases, but use is accompanied by a significant burden of adverse effects. It has been hypothesized that gene- and cell-specific regulation of the glucocorticoid receptor by small molecule ligands could be
Jennifer M Rojas et al.
Toxicologic pathology, 46(7), 777-798 (2018-10-23)
The obese rodent serves as an indispensable tool for proof-of-concept efficacy and mode-of-action pharmacology studies. Yet the utility of this disease model as an adjunct to the conventional healthy animal in the nonclinical safety evaluation of anti-obesity pharmacotherapies has not
João Paulo Steffens et al.
Journal of periodontology, 91(4), 545-553 (2019-08-08)
Sex hormone therapy has strict recommendations in the treatment of postmenopausal symptoms, in which testosterone (TES) replacement may play a potential role. However, it remains unclear whether TES affects the course of chronic inflammation and alveolar bone loss in females.

相关内容

Multiplexing Metabolic Syndrome Biomarkers | MILLIPLEX® Assays

Multiplex immunoassays, such as MILLIPLEX® multiplex metabolic assays, are critical in metabolic syndrome research because they provide a full picture of the different conditions related to it, like diabetes and obesity, as well as save time and sample volume.

兽医学和动物健康研究的多重检测 | MILLIPLEX®检测试剂盒

了解在实验室、伴生和农业动物研究中使用生物标志物多重免疫检测产品的优势，探索MILLIPLEX®多重检测试剂盒在兽医学和动物健康研究方面的应用。

Protocol- RBN1MAG-31K
Quality Control Ranges: Milliplex Rat Bone Panel and Milliplex Rat Osteopontin Single Plex Kit
查看所有结果

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持