跳转至内容
Merck
CN

RKTX1MAG-37K

MILLIPLEX® 大鼠肾毒性磁珠面板1-毒性多重测定

Configurable Rat Kidney Toxicity 7-Plex Panel

别名:

Rat renal damage panel, kidney injury biomarker panel for rats, rat drug safety kidney panel, rat nephrotoxicity multiplex assay, rat renal inflammation assay

登录 查看组织和合同定价。

关于此项目

UNSPSC Code:
12161503
NACRES:
NA.84
eCl@ss:
32161000

主要文件

查看所有文档
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助

产品名称

MILLIPLEX® 大鼠肾毒性磁珠面板1-毒性多重测定, Configurable Rat Kidney Toxicity 7-Plex Panel

species reactivity

rat

Quality Level

200

assay range

accuracy: 70-123%
standard curve range: 0.03-20 ng/mL
(IP-10, KIM-1, OPN)
standard curve range: 0.03-20 ng/mL
(VEGF)
standard curve range: 0.27-200 ng/mL
(TIMP-1)
standard curve range: 2.06-1500 ng/mL
(Clusterin)
standard curve range: 4.12-3000 ng/mL
(GSTα)
inter-assay cv: <10%
intra-assay cv: <15%
(All other analytes)
inter-assay cv: <20%
intra-assay cv: <30%
(GSTα)

technique(s)

multiplexing: suitable

input

urine

packaging

pkg of 1 ea

manufacturer/tradename

Milliplex®

detection method

fluorometric (Luminex® xMAP® technology)

shipped in

wet ice

storage temp.

2-8°C

相关类别

Application

MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 7 analytes in rat urine samples.

Analytes Included: Clusterin, GSTα, IP-10/CXCL10, KIM-1, Osteopontin (OPN), TIMP-1, VEGF-A Note: GSTα is in a competitive assay format.

Assay Characteristics: Refer to the assay protocol for details on cross-reactivity, sensitivity, precision, and accuracy.

Disclaimer

For research use only. Not for use in diagnostic procedures.

Label License/Sticker for Assay Product:

By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

Features and Benefits

Features:
  • Multiplex detection of 7 kidney injury biomarkers in one assay
  • Magnetic bead-based format for efficient and reproducible processing
  • Compatible with urine samples
  • High sensitivity for early detection of renal damage
Benefits:
  • Conserves sample volume and reagents through multiplexing
  • Improves data quality and reproducibility with magnetic bead format
  • Enables early detection and monitoring of kidney injury

General description

KIM-1, Clusterin, and GSTα are sensitive indicators of tubular injury and cellular stress. IP-10/CXCL10 and TIMP-1 reflect renal inflammation and tissue remodeling. OPN and VEGF-A are involved in fibrosis and vascular responses. Together, these biomarkers offer a comprehensive view of kidney toxicity and repair mechanisms in rat models.

Legal Information

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

法规信息

新产品
此项目有

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Javad Habibi et al.
Cardiovascular diabetology, 18(1), 40-40 (2019-03-27)
Diabetic nephropathy (DN) is characterized by glomerular and tubulointerstitial injury, proteinuria and remodeling. Here we examined whether the combination of an inhibitor of neprilysin (sacubitril), a natriuretic peptide-degrading enzyme, and an angiotensin II type 1 receptor blocker (valsartan), suppresses renal
Kidney biomarkers in MCPA-induced acute kidney injury in rats: reduced clearance enhances early biomarker performance.
Wunnapuk, K; Liu, X; Gobe, GC; Endre, ZH; Peake, PW; Grice, JE; Roberts, MS; Buckley, NA
Toxicology Letters null
Iwan P Williams et al.
mAbs, 12(1), 1685349-1685349 (2019-11-27)
IgE monoclonal antibodies hold great potential for cancer therapy. Preclinical in vivo systems, particularly those in which the antibody recognizes the host species target antigen and binds to cognate Fc receptors, are often the closest approximation to human exposure and
Nadeeka S Udawatte et al.
Frontiers in pharmacology, 11, 511-511 (2020-05-12)
Candida albicans is the major fungal species associated with superficial mucosal infections such as oral candidiasis as well as systemic mycoses with high morbidity and mortality. On top of the rising drug resistance, currently available antifungal agents have significant adverse
Klintean Wunnapuk et al.
Toxicology letters, 225(1), 192-200 (2013-12-24)
Accidental or intentional ingestion of glyphosate surfactant-based herbicides, like Roundup(®), leads to nephrotoxicity as well as death. In this study, a panel of kidney injury biomarkers was evaluated in terms of suitability to detect acute kidney injury and dysfunction. The

相关内容

Multiplex Toxicity Assays | MILLIPLEX® Assays

Multiplex toxicity assays enable researchers to simultaneously measure multiple toxicity biomarkers of various organs to gain a better understanding of toxicity. Explore how MILLIPLEX® multiplex toxicity assays are advancing research on liver injury, kidney toxicity, genotoxicity, and more.

Nephrotoxicity Analysis with Kidney Toxicity Multiplex Assays | MILLIPLEX® Assays

Novel kidney toxicity biomarkers expand options for acute nephrotoxicity detection. Multiplex assays measure multiple renal damage biomarkers in small sample volumes, minimizing time and costs. See how MILLIPLEX® multiplex kidney toxicity assays detected vancomycin-induced subacute nephrotoxicity in rat models.

兽医学和动物健康研究的多重检测 | MILLIPLEX®检测试剂盒

了解在实验室、伴生和农业动物研究中使用生物标志物多重免疫检测产品的优势，探索MILLIPLEX®多重检测试剂盒在兽医学和动物健康研究方面的应用。

Multiplex analysis of urinary protein biomarkers for the detection of Vancomycin-induced subacute nephrotoxicity
查看所有结果

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持