CPGWIZ^™ Oct-4

FUNCTION: SwissProt: Q01860 # Transcription factor that binds to the octamer motif (5′-ATTTGCAT-3′). Prime candidate for an early developmental control gene.
SIZE: 360 amino acids; 38571 Da
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Ubiquitous. Expressed at low levels.
SIMILARITY: SwissProt: Q01860 ## Belongs to the POU transcription factor family. Class- 5 subfamily. & Contains 1 homeobox DNA-binding domain. & Contains 1 POU-specific domain.
MISCELLANEOUS: Several pseudogenes of POU5F1 have been described on chromosomes 1, 3, 8, 10 and 12. 2 of them, localized in chromosomes 8 and 10, are transcribed in cancer tissues but not in normal ones and may be involved in the regulation of POU5F1 gene activity in carcinogenesis.

The components of the CPG WIZ Oct-4 Amplification Kit include those required for PCR amplification after bisulfite modification of DNA samples. Sufficient reagents are provided to analyze 25 samples with appropriate controls. U Primer Set7.5 μM each primer (25X) / 35 μL / 2003416 /-15°C to -25°C M Primer Set7.5 μM each primer (25X) / 35 μL / 2003417 / -15°C to -25°C W Primer Set7.5 μM each primer (25X) / 35 μL / 2003511 / -15°C to -25°C Universal 10X PCR Buffer / 265 μL / 90396 / -15°C to -25°C

CPGWIZ is a trademark of Merck KGaA, Darmstadt, Germany

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