HGT-1 Human Gastric Cancer Cell Line

Gastric adenocarcinoma is the most common type of gastric cancer, representing 95% of malignancies that originate in the stomach (1). The incidence of gastric adenocarcinoma is especially high in Central and Eastern Asia and areas of Eastern Europe and South America, comprising a significant global health burden (1). Robust models of gastric cancer that reflect the most prevalent form of this disease are therefore highly valuable.

References:
1. Nat Rev Dis Primers 2017; 3: 17036.
2. Cancer Res 1982; 42(4): 1541-1548.

The HGT-1 human gastric cancer cell line is derived from a poorly-differentiated adenocarcinoma and is well-established as a model for studies of gastric cancer and mechanisms of gastric secretion. HGT-1 cells are tumorigenic in nude mice and have a hyperdiploid karyotype (2). HGT-1 cells do not secrete mucus, yet maintain expression of functional histamine H2 receptors also found in normal acid-secreting parietal cells (2).

Source:
The HGT-1 cell line was established from a primary tumor of a 60-year-old male patient (2).

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Store in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.