Caco-2/TC-7 Human Colon Adenocarcinoma Cell Line

Caco-2/TC-7 Human Colon Adenocarcinoma Cell Line was isolated from a late passage of the parental Caco-2 cell line and comprises a more homogeneus population of cells that exhibit the characteristic functions of small intestinal enterocytes including organization of the apical brush border, distribution of the associated hydrolase sucrase-isomaltase (SI), more developed interceliular tight junctions and a shorter differentiation time (1).Reference:1. J. Cell Sci. 1994; 107(Pt 1): 213-225

• Each vial contains ≥ 1X10⁶ viable cells.• Cells are tested negative for infectious diseases by a Human Essential CLEAR panel by Charles River Animal Diagnostic Services.• Cells are verified to be of human origin and negative for inter-species contamination from rat, mouse, chinese hamster, Golden Syrian hamster, and non-human primate (NHP) as assessed by a Contamination CLEAR panel by Charles River Animal Diagnostic Services.• Cells are negative for mycoplasma contamination.• Each lot of cells is genotyped by STR analysis to verify the unique identity of the cell line.

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Caco-2/TC-7 human colon adenocarcinoma cell line is a useful model for intestinal drug permeability and absorption studies.

This product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation.

Store in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.