CUTLL1 Human T-cell Lymphoblastic Lymphoma Cell Line

T-cell acute lymphoblastic lymphoma (T-ALL) is a rare but aggressive form of non-Hodgkin lymphoma, with a high relapse rate and poor long-term survival (1). The majority of T-cell lymphoblastic leukemias and lymphomas harbors activating mutations in the NOTCH1 gene, a key signaling component required for T-cell development (2). Drugs targeting the Notch pathway are thus promising avenues for treatment of T-cell lymphoblastic leukemias. Lack of response of human T-ALL cell lines to Notch inhibitors has hampered the clinical applicability of these models.

CUTLL1 is a human T-cell lymphoblastic lymphoma cell line derived from a relapsed patient that harbors a t(7;9)(q34;q34) chromosomal translocation resulting in expression of a TCRB-NOTCH1 fusion transcript and aberrant Notch signaling (3). CUTLL1 cells demonstrate high sensitivity to gamma-secretase inhibitors, which act on the Notch pathway. CUTLL1 cells express markers of immature T-cells including CD3, CD4, CD8 and TCRαα (3).

Source:
The CUTLL1 cell line was established from pleural effusion of a relapsed 14-year-old male patient suffering from T-cell lymphoblastic lymphoma (2)

References:
1. Cancer J. 2012; 18(5): 432-8.
2. Science 2004; 306(5694): 269-71.
3. Leukemia 2006; 20(7): 1279-87.

The CUTLL1 cell line is a valuable and clinically relevant model for T-cell lymphoblastic lymphoma.

Store in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.

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