SF295 Human Glioblastoma Cell Line

Glioblastoma multiforme is the most common and malignant primary brain tumor in adults, with a high recurrence rate and a five-year survival rate of less than 5% (1). Nearly 50% of glioblastomas originate in the frontal or temporal lobes of the brain (1). Glioblastomas are the most aggressive form of cancer and demonstrate a high degree of chemotherapy resistance, highlighting the importance of relevant human patient-derived cell models for advancing research into characteristics and treatment of this disease.

SF295 is a patient-derived glioblastoma cell line originating from a temporal lobe tumor (2). SF295 cells do not express the glial markers GFAP or glutamine synthetase, but have been shown to positively express neurofibromin-1, identified as one of the most frequently mutated factors in glioblastoma multiforme (3). SF295 cells exhibit hypertriploidy and glial-like morphology in culture and are non-tumorigenic in athymic mice (2). The SF295 cell line is highly published in studies of chemotherapeutic treatments for glioblastoma, representing a valuable cellular model for assessment of drugs and molecular modulators for their effect on glioblastomas.

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The SF295 glioblastoma cell line was derived from the left frontal lobe tumor of a 67-year-old female patient (2).

Research Category:
Cancer

Human, Cancer Cells

&ge;1X10⁶ cells/vial

Store in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.

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