3dGRO^® Human Lung Organoids (LPTO.245)

Patient-derived lung organoids (lung PDOs) are adult tissue derived in vitro cultured “mini-lungs” that accurately replicate the histological and functional aspects of in vivo lung tissue. Lung organoids have been shown to contain all 6 major lung epithelial cell types including AEC2s, AEC1s, basal cells, club cells, goblet cells and ciliated cells. These 3D organoid models have become attractive alternatives to traditional PDX and animal lung models to study pulmonary diseases including COPD, cystic fibrosis, SARS-CoV-2, viral infections, asthma, and lung cancer. The 3dGRO^® Human Lung Organoids are high quality cryopreserved cell lines derived from patient-derived xenografts, primary tumors or metastatic patient tissues from various regions of the human lung (acinar, papillary, solid, squamous, mucinous). These lung organoids are highly characterized and express lung airway markers including EPCAM, cytokeratin (CK5, CK7), acetyl-tubulin, surfactant proteins (SFTPB/SFTPC), TTF1, P63 and Muc5AC.

Cell Line Characteristics

• Sex: Female
• Age: 69
• Organ: Lung (Primary Tumor, Pleural Fluid)
• Disease: Adenocarcinoma

3dGRO^® human lung organoids should be stored in liquid nitrogen.

3dGRO^® is a trademark of Merck KGaA, Darmstadt, Germany.
3dGRO^® organoids were derived utilizing HUB Organoid Technology.

Subject to local law, this product is intended to be sold for internal in vitro research use only subject to terms and conditions found here: www.sigmaaldrich.com/pdouse. This product may not be re-engineered or copied; used to make derivatives or modifications; used to develop, test, or manufacture a commercial product; used as a component in a commercial product; resold or licensed; used in any clinical applications or trials; or used in humans. A license or limited commercial use agreement is required for use by any for-profit entity, use in services, and use in sponsored academic research. For information regarding any such use, please contact organoids@milliporesigma.com.

3dGRO is a registered trademark of Merck KGaA, Darmstadt, Germany

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.