BioTracker PyrPeg Amyloid-b Live Cell Dye

Alzheimer′s disease (AD) is a progressive neurological disorder characterized by the presence of amyloid-beta (Aβ) plagues and neurofibrillary tangles. The accumulation of Aβ plaques is an early event in the pathogenesis of AD. In AD research, there has been a growing need for in vivo Aβ imaging by two-photon microscopy, which enables deep-brain-fluorescence imaging. BioTracker PyrPeg Amyloid-b Live Cell Dye is a two-photon fluorescent probe that specifically detects insoluble Aβ, rather than tau and alpha-synuclein aggregates (1). This probe may serve as a useful blood-brain-barrier penetrating tool for optical and functional monitoring of insoluble forms of Aβ aggregates in the AD model brain (1).Reference:1. Choi, Ji-Woo, et al. "PyrPeg, a Blood–Brain-Barrier-Penetrating Two-Photon Imaging Probe, Selectively Detects Neuritic Plaques, Not Tau Aggregates." ACS Chemical Neuroscience 11.12 (2020): 1801-1810.

Purity ≥ 98% confirmed by HPLC. Identification confirmed by HNMR, LC-MS, and elemental analysis.

Two-photon fluorescent probe for imaging insoluble forms of Amyloid-beta aggregates in Alzheimer′s disease studies.

Lyophilized. Orange solid.

Store at -20°C, desiccate and protect from light.
Note: Centrifuge vial briefly to collect contents at bottom of vial before opening

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