InChI key
PVKSNHVPLWYQGJ-KQYNXXCUSA-N
InChI
1S/C10H17N6O12P3/c11-8-5-9(13-2-12-8)16(3-14-5)10-7(18)6(17)4(27-10)1-26-31(24,25)28-30(22,23)15-29(19,20)21/h2-4,6-7,10,17-18H,1H2,(H,24,25)(H2,11,12,13)(H4,15,19,20,21,22,23)/t4-,6-,7-,10-/m1/s1
SMILES string
[Li+].[Li+].[Li+].[Li+].[H]O[H].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)NP([O-])([O-])=O)[C@@H](O)[C@H]3O
form
powder
mol wt
Mr 506.2 (ANP-PNP), Mr 529.9 (AMP-PNP-Li4)
packaging
pkg of 25 mg
manufacturer/tradename
Roche
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Analysis Note
污染物：≤1.5% Pi，<0.1% ATP (酶法)
Application
AMP-PNP是大多数ATP性依赖系统的竞争性抑制剂。α- 和 β磷原子键水解的良好底物，但耐受性β- 和 γ磷原子键裂解酶。蛇毒磷酸二酯酶和腺苷酸环化酶底物。
AMP-PNP已用于双动力荧光检测。
AMP-PNP已用于双动力荧光检测。
亚胺二磷酸腺苷已用于制备核苷酸溶液，双动力荧光检测结合肌动蛋白制备流动细胞以及级联结合反应。
Features and Benefits
内容物
88% AMP-PNP（N 端），4.5%锂，5%水
88% AMP-PNP（N 端），4.5%锂，5%水
General description
AMP-PNP（亚胺二磷酸腺苷）是ATP的非水解类似物。它可抑制快速轴突转运，促进膜性细胞器和微管之间的相互作用。
AMP-PNP（亚胺二磷酸腺苷）是腺苷酸环化酶的一种人造底物。腺苷酸环化酶水解亚胺二磷酸腺苷的速度比ATP慢。
Other Notes
仅用于生命科学研究。不可用于诊断。
Preparation Note
-15至-25°C储存。（干燥储存！）
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
High accuracy measurements of nanometer-scale distances between fluorophores at the single-molecule level
Niekamp S, et al.
bioRxiv, 234740-234740 (2017)
Arthur Chow et al.
Methods in enzymology, 667, 365-402 (2022-05-08)
Pseudokinases often operate through functionally related enzymes and receptors. A prime example is the pseudokinase KSR (Kinase Suppressor of RAS), which can act as both an amplifier and inhibitor of members in the RAS-MAPK (Mitogen Activated Protein Kinase) signaling pathway.
Nucleotide dependence of the dimerization of ATP binding cassette nucleotide binding domains
Fendley GA, et al.
Biochemical and Biophysical Research Communications, 480(2), 268-272 (2016)
S T Brady
Nature, 317(6032), 73-75 (1985-09-05)
Identification of the ATPase involved in fast axonal transport of membranous organelles has proven difficult. Myosin and dynein, other ATPases known to be involved in cell motility, have properties that are inconsistent with the established properties of fast axonal transport
Cristina Olivieri et al.
eLife, 9 (2020-04-28)
In the nucleus, the spatiotemporal regulation of the catalytic subunit of cAMP-dependent protein kinase A (PKA-C) is orchestrated by an intrinsically disordered protein kinase inhibitor, PKI, which recruits the CRM1/RanGTP nuclear exporting complex. How the PKA-C/PKI complex assembles and recognizes
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