assay
98%
form
crystalline powder
mol wt
334.3
packaging
pkg of 2 mg
manufacturer/tradename
Roche
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
mode of action
DNA synthesis | interferes
storage temp.
2-8°C
SMILES string
N21[C@]([C@H]4N[C@H]4C2)([C@@H](C3=C1C(=O)C(=C(C3=O)N)C)COC(=O)N)OC
InChI
1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1
InChI key
NWIBSHFKIJFRCO-WUDYKRTCSA-N
General description
丝裂霉素 C 是一种抗肿瘤抗生素
Application
丝裂霉素 C 已用于:
- 终止有丝分裂
- 在磷酸盐缓冲生理盐水(PBS)中用于小鼠胚胎成纤维细胞(MEF)的灭活和铺板
- 致突变性测定中的诱变剂
丝裂霉素 C 可用作研究无细胞蛋白质生物合成的抑制剂。它也抑制 DNA 合成。它已被用作肿瘤细胞的遗传毒物。
Biochem/physiol Actions
丝裂霉素 C(MMC)可作为具有生物还原性烷基化作用的药物的原型。它在厌氧条件下具有活性。MMC 在胃癌、胰腺癌和乳腺癌中表现出广泛的临床抗肿瘤性质。
Other Notes
仅用于生命科学研究。不用于诊断操作。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral - Carc. 2
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
does not flash
flash_point_c
does not flash
法规信息
监管及禁止进口产品
此项目有
商品
Antibiotic kill curve is a dose response experiment in which mammalian cells are subjected to increasing amounts of selection antibiotic
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Pathogenic germline mutations in the RAD51 paralog genes RAD51C and RAD51D, are known to confer susceptibility to ovarian and triple-negative breast cancer. Here, we investigated whether germline loss-of-function variants affecting another RAD51 paralog gene, RAD51B, are also associated with breast
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Oncoimmunology, 11(1), 2080329-2080329 (2022-06-04)
MHC class II expression is a hallmark of professional antigen-presenting cells and key to the induction of CD4+ T helper cells. We found that these molecules are ectopically expressed on tumor cells in a large proportion of patients with pancreatic
Sertoli cell-mediated differentiation of bovine fetal mesenchymal stem cells into germ cell lineage using an in vitro co-culture system
Segunda MN, et al.
Theriogenology, 130, 8-18 (2019)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 10107409001 | 04061838258823 |

