biological source
yeast
form
lyophilized
specific activity
~20 units/mg protein (At 25 °C with acetaldehyde as the substrate.)
packaging
pkg of 250 U
manufacturer/tradename
Roche
optimum pH
8.75
relevant disease(s)
cancer
storage temp.
2-8°C
Quality Level
General description
乙醛脱氢酶（ALDH）是一种可溶性酶，活性依赖于钾离子和半胱氨酸。ALDH家族由19个人类基因组成。ALDH基因在细胞核、胞质、线粒体和内质网中表达。ALDH是烟酰胺腺嘌呤二核苷酸磷酸（NADH）和烟酰胺腺嘌呤二核苷酸磷酸（NADPH）循环系统的组成部分。
Application
乙醛脱氢酶已用于评估光纤生物传感器，从而测定液相中的乙醛（AcH）（AcH生物传感器）。
Biochem/physiol Actions
乙醛脱氢酶（ALDH）可调节非P450乙醛还原酶系统。它可保护细胞免受有毒乙醛的影响。该基因的突变与Sjogren Larsson综合征、Larsson综合征、II型高蛋白血症和癌症相关。ALDH参与了乙醛氧化成酸的反应。ALDH-2可降低因心肌梗塞或心脏手术后出现的心脏缺血。
Physical form
用磷酸钾缓冲液（pH 值约为 6）稳定酶。
Analysis Note
污染物： 分别是 <0.01%“NADH氧化酶”、ADH 和 LDH
Other Notes
仅用于生命科学研究。不可用于诊断。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Inhalation - STOT RE 2
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
does not flash
flash_point_c
does not flash
法规信息
常规特殊物品
此项目有
Improved sensitivity of acetaldehyde biosensor by detecting ADH reverse reaction-mediated NADH fluoro-quenching for wine evaluation
Iitani K, et al.
ACS sensors, 2(7), 940-946 (2017)
Yeast Aldehyde Dehydrogenase II. PROPERTIES OF THE HOMOGENEOUS ENZYME PREPARATIONS
Charles R. Steinman and WILLIAM B. JAKOBY
The Journal of Biological Chemistry, 243(4), 730-734 (1965)
Kenta Iitani et al.
Sensors (Basel, Switzerland), 23(13) (2023-07-14)
The molecule 2-nonenal is renowned as the origin of unpleasant human aging-related body odor that can potentially indicate age-related metabolic changes. Most 2-nonenal measurements rely on chromatographic analytical systems, which pose challenges in terms of daily usage and the ability
Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart
Chen CH, et al.
Science (New York, N.Y.), 321(5895), 1493-1495 (2008)
Yeast aldehyde dehydrogenase.
S BLACK
Archives of biochemistry and biophysics, 34(1), 86-97 (1951-11-01)
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