产品名称
NAD, Grade I, free acid
InChI
1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1
SMILES string
NC1=NC=NC2=C1N=CN2.O[C@@H]3[C@@H](COP(O)(OP(OC[C@@H](O4)[C@@H](O)[C@@H](O)[C@H]4[N+]5=CC=CC(C(N)=O)=C5)([O-])=O)=O)OC[C@@H]3O
InChI key
BAWFJGJZGIEFAR-NNYOXOHSSA-N
assay
100% (dry weight)
form
lyophilized
mol wt
Mr 663.4
packaging
pkg of 1 g (10127965001)
pkg of 5 g (10127973001)
manufacturer/tradename
Roche
color
off-white
pH
~3.0 (50 mg/mL in water)
λmax
260 nm
shipped in
wet ice
storage temp.
2-8°C
正在寻找类似产品? 访问 产品对比指南
Analysis Note
纯度：以干重（酶促、CN-配合物和吸光度）计，100％ β-NAD；A250nm - A260nm：0.83 ± 0.02，A280nm - A260nm：0.22 ± 0.02
不含污染物：检测不到LDH抑制剂
有机溶剂： =0.05%（GC）
不含污染物：检测不到LDH抑制剂
有机溶剂： =0.05%（GC）
Application
I级NAD（烟酰胺腺嘌呤二核苷酸）用于人类第IV类乙醇脱氢酶的动力学研究。
NAD可用于体外糖原合酶激酶3（GSK3）的脱乙酰化分析。它也可用在酶联动力学测定动力学特征的测定过程中，作为测定混合物的组分之一。
Biochem/physiol Actions
NAD还参与微生物的分解代谢。β-NAD在几种细胞过程中充当各种酶的底物。
NAD（烟酰胺腺嘌呤二核苷酸）/NADH比可调节细胞内的氧化还原电位，从而影响体内代谢反应。它是电子受体。
电子受体
Features and Benefits
吸光系数：在260 nm处为17.6 x 103l x mol-1 x cm-1 ，333 nm处为5.9 x 103l x mol-1 x cm-1（CN-配合物）
General description
烟酰胺腺嘌呤二核苷酸（NAD）是一种普遍存在的 电子载体 和辅助因子。NAD+包含通过焦磷酸部分连接在一起的腺苷酸和烟酰胺-5′-核糖核苷酸基团。在NAD+复合物中，酶-辅因子的相互作用高度保守。
Other Notes
仅用于生命科学研究。不可用于诊断。
本品是普通型 NAD。
Packaging
根据固体质量包装。
Preparation Note
储存条件（工作液）：在2至8℃下储存4周后，10 mg/ml的水溶液中至少含有99％的NAD
存储类别
13 - Non Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
The kinetic characteristics of human and trypanosomatid phosphofructokinases for the reverse reaction
Fernandes PM, et al.
The Biochemical Journal, 476(2), 179-191 (2019)
SIRT2 deacetylase regulates the activity of GSK3 isoforms independent of inhibitory phosphorylation
Sarikhani M, et al.
eLife, 7(1), e32952-e32952 (2018)
N J Hughes et al.
Journal of bacteriology, 180(5), 1119-1128 (1998-03-12)
Helicobacter pylori, a major cause of human gastric disease, is a microaerophilic bacterium that contains neither pyruvate nor 2-oxoglutarate dehydrogenase activity. Previous studies (N. J. Hughes, P. A. Chalk, C. L. Clayton, and D. J. Kelly, J. Bacteriol. 177:3953-3959, 1995)
Jinrui Zhang et al.
Scientific reports, 5, 12846-12846 (2015-08-06)
Eukaryotic metabolism is organised in complex networks of enzyme catalysed reactions which are distributed over different organelles. To quantify the compartmentalised reactions, quantitative measurements of relevant physiological variables in different compartments are needed, especially of cofactors. NADP(H) are critical components
Chu-Fang Chou et al.
The Journal of biological chemistry, 277(28), 25209-25216 (2002-05-09)
Molecular genetic studies have indicated that alcohol dehydrogenase may be involved in the synthesis of retinoic acid, a hormonal molecule regulating diverse cellular functions at the transcriptional level. Class IV alcohol dehydrogenase (ADH) has been reported to be the most
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持