产品名称
抗-HA（12CA5）, from mouse IgG2bκ
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
12CA5, monoclonal
assay
>90% (HPLC and SDS-PAGE)
form
frozen liquid (11666606001)
lyophilized (11583816001)
packaging
pkg of 200 μg (11583816001)
pkg of 5 mg (11666606001 [1 ml])
manufacturer/tradename
Roche
concentration
5 mg/ml (11666606001)
isotype
IgG2bκ
epitope sequence
YPYDVPDYA
storage temp.
−20°C
Quality Level
Analysis Note
每批抗HA抗体的免疫反应性和纯度已相对于参考标准品进行检测。
Application
使用抗HA（12CA5）对天然流感血凝素蛋白和重组HA标签蛋白进行检测：
- 斑点印迹
- 免疫组化
- 免疫沉淀
- 蛋白质印迹
Biochem/physiol Actions
抗HA（12CA5）可识别来自人流感血凝素（HA）蛋白的9-氨基酸序列YPYDVPDYA。无论该表位位置如何（N末端、C末端或内部），其也可在融合蛋白中被识别。
膜融合和受体结合作用是血凝素（HA）的关键功能，它有助于病毒的进入和感染。HA是一种流感病毒糖蛋白，其在病毒进入和感染期间可调节膜融合和受体结合功能。病毒可通过内吞作用和HA抗原介导的连续膜融合进入宿主细胞。Ha在病毒发病机制和宿主对病毒感染的反应中起关键作用。
General description
血凝素HA是存在于流感病毒表面上的显性抗原。HA是一个同源三聚体，其中每个单体均为单一的多肽。该单体会被宿主蛋白酶切割成两个亚基HA1和HA2。HA基因定位于B型流感病毒基因组的第4区段。
Immunogen
来自人流感病毒血凝素蛋白的氨基酸98-106。
Other Notes
仅用于生命科学研究。不可用于诊断。
Preparation Note
11 583 816 001: 加入0.5ml PBS至终浓度为0.4mg/ml。
工作浓度：结合物的工作浓度取决于应用和底物。
以下浓度可作为指导：
以下浓度可作为指导：
- 斑点印迹：0.1至1μg/ml
- 免疫荧光：1至-10μg/ ml
- 蛋白质印迹：0.1至1μg/ml
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存储类别
13 - Non Combustible Solids
flash_point_f
does not flash
flash_point_c
does not flash
法规信息
常规特殊物品
此项目有
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Proceedings of the National Academy of Sciences of the United States of America, 119(40), e2212134119-e2212134119 (2022-09-27)
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