13-2510
8-羟基喹啉
JIS special grade, ≥99.0%
别名:
8-氢氧化喹啉, 8-羟基氮杂萘, 喔星
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关于此项目
经验公式（希尔记法）:
C9H7NO
化学文摘社编号:
分子量:
145.16
EC Number:
205-711-1
UNSPSC Code:
12352104
PubChem Substance ID:
Beilstein/REAXYS Number:
114512
MDL number:
Assay:
≥99.0%
Grade:
JIS special grade
InChI key
MCJGNVYPOGVAJF-UHFFFAOYSA-N
InChI
1S/C9H7NO/c11-8-5-1-3-7-4-2-6-10-9(7)8/h1-6,11H
SMILES string
Oc1cccc2cccnc12
grade
JIS special grade
assay
≥99.0%
form
solid
availability
available only in Japan
dilution
(for analytical testing)
mp
72.5-74.0 °C
antibiotic activity spectrum
fungi
mode of action
DNA synthesis | interferes, enzyme | inhibits
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General description
Chemical structure: quinolone
signalword
Danger
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Repr. 1B - Skin Sens. 1
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
新产品
此项目有
G L Apostoli et al.
Journal of thrombosis and haemostasis : JTH, 12(11), 1880-1889 (2014-08-29)
Nitric oxide (NO) is a critical negative regulator of platelets that is implicated in the pathology of thrombotic diseases. Platelets generate NO, but the presence and functional significance of NO synthase (NOS) in platelets is unclear. Inorganic nitrate/nitrite is increasingly
Erik H J G Aarntzen et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 19(6), 1525-1533 (2013-02-06)
Anticancer dendritic cell (DC) vaccines require the DCs to relocate to lymph nodes (LN) to trigger immune responses. However, these migration rates are typically very poor. Improving the targeting of ex vivo generated DCs to LNs might increase vaccine efficacy
Saverio Tardito et al.
Journal of medicinal chemistry, 55(23), 10448-10459 (2012-11-23)
This study reports the structure-activity relationship of a series of 8-hydroxoquinoline derivatives (8-HQs) and focuses on the cytotoxic activity of 5-Cl-7-I-8-HQ (clioquinol, CQ) copper complex (Cu(CQ)). 8-HQs alone cause a dose-dependent loss of viability of the human tumor HeLa and
Nadia A Al-Banna et al.
European journal of immunology, 44(6), 1633-1643 (2014-04-05)
CCR4 and CXCR3 are expressed on several T-cell subsets in inflamed tissues, yet their role in tissue-specific recruitment is unclear. We examined the contributions of CCR4 and CXCR3 to T-cell recruitment into inflamed joints in collagen-induced arthritis, antigen-draining lymph nodes
Donald J Messner et al.
Digestive diseases and sciences, 58(7), 1899-1908 (2013-04-06)
Iron overload is associated with increased severity of nonalcoholic fatty liver disease (NAFLD) including progression to nonalcoholic steatohepatitis and hepatocellular carcinoma. To identify potential role(s) of iron in NAFLD, we measured its effects on pathways of oxidative stress and insulin
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