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13-2510

8-羟基喹啉

Name: 8-羟基喹啉
Brand: SAJ

JIS special grade, ≥99.0%

别名:

8-氢氧化喹啉, 8-羟基氮杂萘, 喔星

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关于此项目

经验公式（希尔记法）:

C₉H₇NO

化学文摘社编号:

148-24-3

分子量:

145.16

EC Number:

205-711-1

UNSPSC Code:

12352104

PubChem Substance ID:

329750115

Beilstein/REAXYS Number:

114512

MDL number:

MFCD00006807

Assay:

≥99.0%

Grade:

JIS special grade

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属性

grade

JIS special grade

assay

≥99.0%

form

solid

availability

available only in Japan

dilution

(for analytical testing)

mp

72.5-74.0 °C

antibiotic activity spectrum

fungi

mode of action

DNA synthesis | interferes, enzyme | inhibits

SMILES string

Oc1cccc2cccnc12

InChI

1S/C9H7NO/c11-8-5-1-3-7-4-2-6-10-9(7)8/h1-6,11H

InChI key

MCJGNVYPOGVAJF-UHFFFAOYSA-N

说明

General description

Chemical structure: quinolone

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pictograms

GHS06,GHS08,GHS05,GHS09

signalword

Danger

hcodes

H301,H317,H318,H360D,H410

pcodes

P202 - P273 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Repr. 1B - Skin Sens. 1

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

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历史批次信息供参考:

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Role of inorganic nitrate and nitrite in driving nitric oxide-cGMP-mediated inhibition of platelet aggregation in vitro and in vivo.

G L Apostoli et al.

Journal of thrombosis and haemostasis : JTH, 12(11), 1880-1889 (2014-08-29)

Nitric oxide (NO) is a critical negative regulator of platelets that is implicated in the pathology of thrombotic diseases. Platelets generate NO, but the presence and functional significance of NO synthase (NOS) in platelets is unclear. Inorganic nitrate/nitrite is increasingly

An asymmetric synthesis of 1,2,4-trioxane anticancer agents via desymmetrization of peroxyquinols through a Brønsted acid catalysis cascade.

David M Rubush et al.

Journal of the American Chemical Society, 134(33), 13554-13557 (2012-08-09)

The desymmetrization of p-peroxyquinols using a Brønsted acid-catalyzed acetalization/oxa-Michael cascade was achieved in high yields and selectivities for a variety of aliphatic and aryl aldehydes. Mechanistic studies suggest that the reaction proceeds through a dynamic kinetic resolution of the peroxy

Copper-dependent cytotoxicity of 8-hydroxyquinoline derivatives correlates with their hydrophobicity and does not require caspase activation.

Saverio Tardito et al.

Journal of medicinal chemistry, 55(23), 10448-10459 (2012-11-23)

This study reports the structure-activity relationship of a series of 8-hydroxoquinoline derivatives (8-HQs) and focuses on the cytotoxic activity of 5-Cl-7-I-8-HQ (clioquinol, CQ) copper complex (Cu(CQ)). 8-HQs alone cause a dose-dependent loss of viability of the human tumor HeLa and

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全球贸易项目编号

货号	GTIN
13-2510-5-500G-J	04061832684796