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线性分子式:
[HOC6H3(OCH3)CH=CHCO]2CH2
化学文摘社编号:
分子量:
368.38
EC Number:
207-280-5
UNSPSC Code:
85151701
NACRES:
NA.24
PubChem Substance ID:
MDL number:
Colour Index Number:
75300
Beilstein/REAXYS Number:
2306965
产品名称
姜黄素, primary reference standard
InChI key
VFLDPWHFBUODDF-FCXRPNKRSA-N
InChI
1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+
SMILES string
COc1cc(\C=C\C(=O)CC(=O)\C=C\c2ccc(O)c(OC)c2)ccc1O
grade
primary reference standard
vapor density
13 (vs air)
form
powder or crystals
shelf life
limited shelf life, expiry date on the label
manufacturer/tradename
HWI
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
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Application
已在 1H NMR 和 LC–MS/MS 分析中作为参比标准品用于定量姜黄中的姜黄素。
草药药品分析中的参比标准品
Biochem/physiol Actions
一种天然酚类化合物。它是有效的抗肿瘤剂，具有抗炎和抗氧化活性。除了具有化疗活性外，姜黄素还被认为是潜在的化学预防剂。它能够诱导癌细胞凋亡并抑制佛波酯诱导的蛋白激酶C（PKC）活性。据报道，它能抑制外周血单核细胞和肺泡巨噬细胞产生炎性细胞因子。它是EGFR酪氨酸激酶和IκB激酶的有效抑制剂。它能抑制诱导型一氧化氮合酶（iNOS）、环加氧酶和脂氧合酶。它易于渗透到细胞质中，在质膜、内质网和核膜等膜结构中积累。
它是一种天然酚类化合物，是姜黄的黄色来源。它是有效的抗肿瘤剂，作用于高度多样化的肿瘤特异性通路。它具有抗炎和抗氧化活性。它能够诱导癌细胞凋亡并抑制佛波酯诱导的蛋白激酶C（PKC）活性。据报道，它能抑制外周血单核细胞和肺泡巨噬细胞产生炎性细胞因子。它是EGFR酪氨酸激酶和IκB激酶的有效抑制剂。它能抑制诱导型一氧化氮合酶（iNOS）、环加氧酶（COX-2）和5-脂氧合酶（5-LOX）。
General description
姜黄素是姜黄的一种生物活性成分。它具有广谱的活性，包括抗氧化，抗炎和抗癌的性质。它已被证明是一种非常强大的抗氧化剂，并已被发现可以增强常见的抗癌药物的效果。它还可以调节多种分子靶点，如细胞因子和趋化因子、多种酶、受体、转录因子、细胞周期蛋白和细胞表面粘附分子。
由 HWI pharma services GmbH 生产并鉴定。
通过定量 NMR 测得的准确含量可参见证书。
通过定量 NMR 测得的准确含量可参见证书。
Other Notes
这种化合物通常存在于蓍属植物中：姜黄属
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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